[The influence on the BK channel beta1 subunit expression of SO caused by high cholesterol in rabbits].
作者信息
Du Pang, Wei Jing-Guo, Cui Guang-Bin, Wang Ya-Rong, Zhang Xiao-Yong, Ma Ke-Jun
机构信息
Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
出版信息
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Nov;22(6):710-2.
AIM
To investigate the effects on protein expression of big-conductance Ca(2+)-sensitive K(+) channel (BKca) beta1 subunit caused by high cholesterol in Rabbit Oddi's sphincter (SO) cells.
METHODS
The rat-anti-rabbit polyclonal antiserum against beta1 subunits of BKca channel of SO cell was prepared. And the protein expression of BKca channel beta1 subunit of SO tissue was detected by semi-quantitative immunohistochemical staining.
RESULTS
The protein expression of BKca channels beta1 subunit of SO tissue in HC group was reduced, and there's statistically significant difference between the HC group and the control group.
CONCLUSION
High cholesterol can reduce the protein expression of BK Channel's beta1 subunit in Rabbits' SO which suggests high cholesterol can affect the function of BKca channel.
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