Kuenne C T, Ghai R, Chakraborty T, Hain T
Institute of Medical Microbiology, Justus-Liebig-University Frankfurter Strasse 107, D-35392 Giessen, Germany.
Bioinformatics. 2007 Jan 1;23(1):125-6. doi: 10.1093/bioinformatics/btl556. Epub 2006 Oct 31.
In order to understand and interpret phylogenetic and functional relationships between multiple prokaryotic species, qualitative and quantitative data must be correlated and displayed. GECO allows linear visualization of multiple genomes using a client/server based approach by dynamically creating .png- or .pdf-formatted images. It is able to display ortholog relations calculated using BLASTCLUST by color coding ortholog representations. Irregularities on the genomic level can be identified by anomalous G/C composition. Thus, this software will enable researchers to detect horizontally transferred genes, pseudogenes and insertions/deletions in related microbial genomes.
http://bioinfo.mikrobio.med.uni-giessen.de/geco2/GecoMainServlet
为了理解和阐释多个原核生物物种之间的系统发育和功能关系，必须对定性和定量数据进行关联与展示。GECO通过基于客户端/服务器的方法动态创建.png或.pdf格式的图像，从而实现多个基因组的线性可视化。它能够通过对直系同源物表示进行颜色编码来展示使用BLASTCLUST计算出的直系同源关系。基因组水平上的不规则性可通过异常的G/C组成来识别。因此，该软件将使研究人员能够在相关微生物基因组中检测水平转移基因、假基因以及插入/缺失。
http://bioinfo.mikrobio.med.uni-giessen.de/geco2/GecoMainServlet
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