Nyirjesy Paul, Peyton Christina, Weitz M Velma, Mathew Leny, Culhane Jennifer F
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.
Obstet Gynecol. 2006 Nov;108(5):1185-91. doi: 10.1097/01.AOG.0000239103.67452.1a.
To compare women with different chronic vaginal symptoms with a wide variety of sociodemographic, health, behavioral, and psychosocial characteristics.
Serially recruited subjects answered a questionnaire that asks about demographic information and symptoms and measures depression and stress scores. Patients underwent a standardized history, physical examination, and laboratory examination. Patients with recurrent vulvovaginal candidiasis, vulvar vestibulitis syndrome, desquamative inflammatory vaginitis, physiologic leukorrhea, and other diagnoses were compared with one another. Chi-square tests and one-way analysis of variance with Tukey honestly significant difference (HSD) post hoc analyses were used for categorical and continuous data analysis.
Two hundred patients were enrolled in this study. The most common diagnoses were contact dermatitis (21%), recurrent vulvovaginal candidiasis (20.5%), atrophic vaginitis (14.5%), and vulvar vestibulitis syndrome (12.5%); 18% of women had 2 or more diagnoses. In the overall study sample, the mean age was 38.4 years, 78% were white, and 55% were college educated. Sixty-two percent had symptoms for over a year. Desquamative inflammatory vaginitis patients were older and less likely to be menstruating. Those with vulvar vestibulitis syndrome had more frequent complaints of dyspareunia. Recurrent vulvovaginal candidiasis patients felt that their symptoms had the greatest negative impact on work and social life. There were high rates of psychiatric disorder (43.5%), atopic disease (42.5%), and pain syndrome (56%) in all groups.
Women with chronic vaginal symptoms have a variety of diagnoses, most of them noninfectious.
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比较具有不同慢性阴道症状的女性在社会人口统计学、健康状况、行为及心理社会特征等方面的差异。
连续招募的受试者回答一份问卷，内容涉及人口统计学信息、症状，并测量抑郁和压力得分。患者接受标准化病史采集、体格检查及实验室检查。对复发性外阴阴道念珠菌病、外阴前庭炎综合征、脱屑性炎症性阴道炎、生理性白带增多及其他诊断的患者进行相互比较。卡方检验及采用Tukey真实显著差异（HSD）事后分析的单因素方差分析用于分类和连续数据分析。
本研究共纳入200例患者。最常见的诊断为接触性皮炎（21%）、复发性外阴阴道念珠菌病（20.5%）、萎缩性阴道炎（14.5%）及外阴前庭炎综合征（12.5%）；18%的女性有2种或更多诊断。在整个研究样本中，平均年龄为38.4岁，78%为白人，55%接受过大学教育。62%的患者症状持续超过一年。脱屑性炎症性阴道炎患者年龄较大，且月经来潮的可能性较小。外阴前庭炎综合征患者性交困难的主诉更为频繁。复发性外阴阴道念珠菌病患者认为其症状对工作和社交生活的负面影响最大。所有组中精神障碍（43.5%）、特应性疾病（42.5%）及疼痛综合征（56%）的发生率均较高。
有慢性阴道症状的女性有多种诊断，其中大多数为非感染性。
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