Den Seika, Shimizu Kazuhiro, Ikeda Tsunehiko, Tsubota Kazuo, Shimmura Shigeto, Shimazaki Jun
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Cornea. 2006 Jul;25(6):651-5. doi: 10.1097/01.ico.0000227889.11500.6f.
To study changes in the lid margin and meibomian glands and their association with aging, sex, and tear function.
We examined 354 eyes in 177 subjects (76 men and 101 women; 21-93 years; mean age, 63.0 +/- 14.3 years) with no ocular symptoms or ocular surface disorders. Anatomic changes in the lid margin were studied using slit-lamp biomicroscopy. Meibomian gland function and morphology were evaluated on the basis of meibum expression and meibography, respectively. Tear function and ocular surface epithelium were assessed with the Schirmer test, by tear film break-up time, and with a fluorescein staining test.
Eyes with abnormal lid margin anatomy, hyposecretion of meibum, and meibomian gland dropout were seen in 26 (7.3%), 46 (12.4%), and 68 eyes (18.6%), respectively, with a significant association between each finding and aging (P = <0.0001, 0.0498, and <0.0001, respectively). In patients < or =69 years of age, no significant association was found between meibomian gland-related findings and sex. However, a high incidence of abnormal lid margin and gland dropout was noted in men > or =70 years of age compared with women. No significant association was found between changes in the lid margin and meibomian glands and tear function in patients > or =40 years of age.
Among symptom-free subjects, we found that changes in the lid margin and meibomian glands were closely related to aging. Among elderly subjects, changes in the anatomic lid margin and meibomian gland morphology were observed more frequently in men than in women. Tear function showed no association with either changes in the lid margin or function of the meibomian glands.
研究睑缘和睑板腺的变化及其与衰老、性别和泪液功能的关系。
我们检查了177名受试者（76名男性和101名女性；年龄21 - 93岁；平均年龄63.0±14.3岁）的354只眼睛，这些受试者无眼部症状或眼表疾病。使用裂隙灯生物显微镜研究睑缘的解剖学变化。分别根据睑脂排出情况和睑板腺造影评估睑板腺功能和形态。通过Schirmer试验、泪膜破裂时间和荧光素染色试验评估泪液功能和眼表上皮。
睑缘解剖结构异常、睑脂分泌减少和睑板腺缺失的眼睛分别有26只（7.3%）、46只（12.4%）和68只（18.6%），每项发现与衰老均有显著相关性（P值分别为<0.0001、0.0498和<0.0001）。在年龄≤69岁的患者中，睑板腺相关发现与性别之间未发现显著相关性。然而，与女性相比，年龄≥70岁的男性睑缘异常和腺体缺失的发生率较高。在年龄≥40岁的患者中，睑缘和睑板腺的变化与泪液功能之间未发现显著相关性。
在无症状受试者中，我们发现睑缘和睑板腺的变化与衰老密切相关。在老年受试者中，男性睑缘解剖结构和睑板腺形态的变化比女性更常见。泪液功能与睑缘变化或睑板腺功能均无关联。
