Marshall Vicky L, Patterson Jim, Hadley Donald M, Grosset Katherine A, Grosset Donald G
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom.
Mov Disord. 2006 Dec;21(12):2247-50. doi: 10.1002/mds.21159.
Between 4% and 14% of patients diagnosed with Parkinson's disease and entering clinical trials have normal presynaptic dopaminergic imaging. The effects of antiparkinsonian therapy have varied in these studies, and the consequences of stopping treatment are not reported. We present 11 patients who initially fulfilled diagnostic criteria and were treated for Parkinson's disease but in whom emerging diagnostic doubts led to antiparkinsonian therapy withdrawal, which was achieved without deterioration. Such cases represent a nondegenerative form of Parkinsonism, which does not benefit from dopaminergic therapy. Prospective vigilance regarding this category is of importance in clinical practice and clinical trials.
在被诊断为帕金森病并进入临床试验的患者中，4%至14%的患者突触前多巴胺能成像结果正常。在这些研究中，抗帕金森病治疗的效果各不相同，且未报告停药的后果。我们报告了11例最初符合诊断标准并接受帕金森病治疗的患者，但后来出现的诊断疑问导致停用抗帕金森病治疗，且停药后病情并未恶化。此类病例代表了一种非退行性帕金森综合征，无法从多巴胺能治疗中获益。在临床实践和临床试验中，对这一类别进行前瞻性监测具有重要意义。
