Penetration enhancement across a model membrane by liposomally entrapped drugs using N,N'-diacylcystine as a bilayer lipid.

A liposomal system for percutaneous absorption and transdermal drug delivery was developed and evaluated using a model apparatus connecting two chambers by a membrane. When N,N'-long chain diacyl L-cystine was incorporated into the liposomal bilayer as well as lecithin and cholesterol, liposomally entrapped calcein as the model drug transferred well across the keratin membrane functioning as the skin model.