抗酒石酸酸性磷酸酶5b（TRACP 5b）作为骨吸收的标志物。

Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption.

作者信息

Halleen Jussi M, Tiitinen Sari L, Ylipahkala Hannele, Fagerlund Katja M, Väänänen H Kalervo

机构信息

Institute ofBiomedicine, Department ofAnatomy, University of Turku, Finland.

出版信息

Clin Lab. 2006;52(9-10):499-509.

PMID:17078477

Abstract

Tartrate-resistant acid phosphatase (TRACP) is an enzyme that is expressed in high amounts by bone resorbing osteoclasts, inflammatory macrophages and dendritic cells. Two forms of TRACP circulate in human blood, TRACP 5a derived from macrophages and dendritic cells, and TRACP 5b derived from osteoclasts. Recent data have demonstrated the utility of TRACP 5b as a marker of osteoclast number and bone resorption, and serum TRACP 5a as a marker of inflammatory conditions. This review summarizes the scientific knowledge on the role of TRACP in osteoclastic bone resorption, the mechanism of TRACP 5b generation in osteoclasts and its secretion into the blood circulation, the methodology of measuring TRACP 5b, diagnostic evidence for the use of TRACP 5b as a resorption marker, and characteristics of TRACP 5b compared to other commonly used bone turnover markers.

摘要

抗酒石酸酸性磷酸酶（TRACP）是一种在骨吸收破骨细胞、炎性巨噬细胞和树突状细胞中大量表达的酶。TRACP的两种形式在人体血液中循环，即源自巨噬细胞和树突状细胞的TRACP 5a，以及源自破骨细胞的TRACP 5b。最近的数据表明，TRACP 5b可作为破骨细胞数量和骨吸收的标志物，而血清TRACP 5a可作为炎症状态的标志物。本综述总结了关于TRACP在破骨细胞性骨吸收中的作用、TRACP 5b在破骨细胞中的生成机制及其分泌到血液循环中的机制、TRACP 5b的测量方法、将TRACP 5b用作吸收标志物的诊断证据，以及与其他常用骨转换标志物相比TRACP 5b的特征等科学知识。