铜催化二乙基锌对源自α-氨基酸的α,β-不饱和亚胺的不对称共轭加成反应。γ-取代的α-脱氢氨基酸酯的对映选择性合成。
Copper-catalyzed asymmetric conjugate addition of diethylzinc to alpha,beta-unsaturated imines derived from alpha-aminoacids. Enantioselective synthesis of gamma-substituted alpha-dehydroaminoesters.
作者信息
Palacios Francisco, Vicario Javier
机构信息
Departamento de Química Organica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria-Gasteiz, Spain.
出版信息
Org Lett. 2006 Nov 9;8(23):5405-8. doi: 10.1021/ol062294k.
PMID:17078729
Abstract
[Structure: see text] A highly enantioselective synthesis of alpha-dehydroaminoacids with a stereogenic center in the gamma position through copper-catalyzed asymmetric conjugate addition of diethylzinc to alpha,beta-unsaturated imines using a TADDOL-derived phosphoramidite complex is reported.
摘要
[结构：见正文] 报道了一种通过使用TADDOL衍生的亚磷酰胺配合物，将二乙基锌铜催化不对称共轭加成到α,β-不饱和亚胺上，来高度对映选择性合成在γ位具有立体中心的α-脱氢氨基酸的方法。
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