Drappatz Jan, Wen Patrick Y
Center for Neuro-oncology Dana-Farber/Brigham and Women's Cancer Center, and Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Expert Rev Neurother. 2006 Oct;6(10):1465-79. doi: 10.1586/14737175.6.10.1465.
As therapy for systemic cancers improves, an increasing number of patients are developing brain metastases. Although conventional therapy with surgery, radiation therapy and radiosurgery has improved the outcome of a significant number of patients, many develop multiple lesions that are not amenable to standard treatments. In this review, the current role of chemotherapy and targeted molecular agents for brain metastases is summarized and future directions are discussed.
随着全身癌症治疗方法的改进，越来越多的患者出现脑转移。尽管手术、放射治疗和立体定向放射外科等传统治疗方法改善了许多患者的预后，但许多患者会出现多个不适合标准治疗的病灶。在这篇综述中，总结了化疗和靶向分子药物在脑转移治疗中的当前作用，并讨论了未来的发展方向。
