Sujak Agnieszka, Strzałka Kazimierz, Gruszecki Wiesław I
Department of Physics, Agricultural University, 20-033 Lublin, Poland.
Chem Phys Lipids. 2007 Jan;145(1):1-12. doi: 10.1016/j.chemphyslip.2006.09.003. Epub 2006 Oct 20.
In this study we address the problem of the effect of canthaxanthin on the thermotropic properties of lipid membranes formed with lipids which differ in the thickness of their hydrophobic core, size of polar heads or presence of the ester carbonyl group. For all the lipids a decrease in main transition enthalpy has been observed, indicating that canthaxanthin alters the membrane properties in its gel phase. The strongest influence of canthaxanthin on main phase transition and pretransition has been observed for the lipid having the thinnest hydrophobic region. Component analysis indicates a distinct cooperativity change, which most probably colligates with the formation of new thermotropic phases. The effect of canthaxanthin has been almost negligible in the case of phosphatidylethanolamines. The absence of the ester carbonyl group results in different thermotropic behavior, especially for low canthaxanthin concentrations. The effect of canthaxanthin is explained in terms of its organization within the membrane.
在本研究中，我们探讨了角黄素对由疏水核心厚度、极性头部大小或酯羰基存在情况不同的脂质形成的脂质膜热致性质的影响。对于所有脂质，均观察到主转变焓降低，这表明角黄素在其凝胶相中改变了膜的性质。对于具有最薄疏水区域的脂质，观察到角黄素对主相变和预转变的影响最强。成分分析表明存在明显的协同性变化，这很可能与新热致相的形成相关。在磷脂酰乙醇胺的情况下，角黄素的影响几乎可以忽略不计。酯羰基的缺失导致不同的热致行为，尤其是在角黄素浓度较低时。角黄素的作用是根据其在膜内的排列来解释的。
