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习得性情境线索增强大鼠进食。

Learned contextual cue potentiates eating in rats.

作者信息

Petrovich Gorica D, Ross Cali A, Gallagher Michela, Holland Peter C

机构信息

Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles St., Baltimore, MD 21218, United States.

出版信息

Physiol Behav. 2007 Feb 28;90(2-3):362-7. doi: 10.1016/j.physbeh.2006.09.031. Epub 2006 Oct 31.

DOI:10.1016/j.physbeh.2006.09.031
PMID:17078980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1892280/
Abstract

Explicit cues associated with food consumption when hunger prevails will enhance eating when they are subsequently presented under conditions of satiety. Here we examined whether contextual conditioned stimuli (CSs) paired with consumption of food pellets while rats were food-deprived would enhance consumption of this food in rats that were not food-deprived. The conditioning context enhanced rats' consumption of the training food, but it did not change their consumption of the familiar, lab chow. These results show that the contextual CSs, like discrete cues, could modulate food consumption in a CS-potentiated eating paradigm. Furthermore, the data suggest that CS-potentiation of eating does not induce a general motivation to eat, akin to hunger, but instead more likely produces a more specific motivational state, akin to craving.

摘要

当饥饿占主导时,与食物消耗相关的明确线索在随后饱腹感条件下出现时会增加进食量。在此,我们研究了在大鼠处于食物剥夺状态时,与食用食丸配对的情境条件刺激(CSs)是否会增加未处于食物剥夺状态的大鼠对这种食物的消耗量。条件化情境增加了大鼠对训练食物的消耗量,但并未改变它们对熟悉的实验室饲料的消耗量。这些结果表明,情境性CSs与离散线索一样,能够在CS增强进食范式中调节食物消耗。此外,数据表明,CS增强进食并不会引发类似于饥饿的一般性进食动机,而是更有可能产生一种类似于渴望的更特定的动机状态。

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本文引用的文献

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Signals that influence food intake and body weight.影响食物摄入量和体重的信号。
Physiol Behav. 2005 Dec 15;86(5):709-16. doi: 10.1016/j.physbeh.2005.08.060. Epub 2005 Nov 2.
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A neural systems analysis of the potentiation of feeding by conditioned stimuli.条件刺激增强进食的神经系统分析。
Physiol Behav. 2005 Dec 15;86(5):747-61. doi: 10.1016/j.physbeh.2005.08.062. Epub 2005 Oct 25.
3
Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating.杏仁核和前额叶通向外侧下丘脑的通路会被一个刺激进食的习得线索激活。
J Neurosci. 2005 Sep 7;25(36):8295-302. doi: 10.1523/JNEUROSCI.2480-05.2005.
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The phenomenology of food cravings: the role of mental imagery.食物渴望的现象学:心理意象的作用。
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Cue-elicited craving for food: a fresh approach to the study of binge eating.线索引发的食物渴望:暴饮暴食研究的新方法。
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Lesions of orbitofrontal cortex impair rats' differential outcome expectancy learning but not conditioned stimulus-potentiated feeding.眶额叶皮质损伤会损害大鼠的差异结果预期学习,但不会损害条件刺激增强的进食行为。
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