Senolt L, Pavelka K, Housa D, Haluzík M
Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.
Cytokine. 2006 Sep;35(5-6):247-52. doi: 10.1016/j.cyto.2006.09.002. Epub 2006 Oct 31.
Adiponectin has been shown to exert insulin-sensitizing, anti-atherogenic, and anti-inflammatory properties in metabolic diseases. It has been suggested that adiponectin may play a role in rheumatoid arthritis (RA). To assess adiponectin in serum and synovial fluid from patients with RA and osteoarthritis (OA), and in serum from healthy controls. Adiponectin and CRP levels were analyzed by ELISA. The clinical activity of RA patients was assessed according to the 28 joint count Disease Activity Score. Synovial fluid adiponectin was significantly higher in RA than in OA patients (p<0.001). Adiponectin was negatively associated with the leukocyte count in RA synovial fluid (r=-0.45, p<0.05). Serum adiponectin was higher in RA compared to healthy controls (p<0.02), however comparable to OA patients. Serum adiponectin was higher than in synovial fluid in both diseases (p<0.001). In general, women had higher adiponectin levels than men. Adiponectin was not related to age, disease duration, body mass index, or disease activity of RA patients. Adiponectin is decreased in synovial fluid compared to serum indicating that peripheral fat stores are major producers of adiponectin into the blood stream. However, increased synovial fluid adiponectin in RA patients may counterpart the local inflammatory process.
脂联素已被证明在代谢性疾病中具有胰岛素增敏、抗动脉粥样硬化和抗炎特性。有人提出脂联素可能在类风湿关节炎（RA）中发挥作用。为了评估类风湿关节炎（RA）和骨关节炎（OA）患者血清及滑液中的脂联素水平，以及健康对照者血清中的脂联素水平。采用酶联免疫吸附测定法（ELISA）分析脂联素和C反应蛋白（CRP）水平。根据28个关节计数疾病活动评分评估RA患者的临床活动度。RA患者滑液中的脂联素水平显著高于OA患者（p<0.001）。RA滑液中的脂联素与白细胞计数呈负相关（r=-0.45，p<0.05）。与健康对照者相比，RA患者血清中的脂联素水平较高（p<0.02），但与OA患者相当。两种疾病中血清脂联素水平均高于滑液中的水平（p<0.001）。总体而言，女性的脂联素水平高于男性。脂联素与RA患者的年龄、病程、体重指数或疾病活动度无关。与血清相比，滑液中的脂联素水平降低，这表明外周脂肪储存是脂联素进入血流的主要来源。然而，RA患者滑液中脂联素水平的升高可能与局部炎症过程相对应。
