Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Sci Rep. 2022 Feb 8;12(1):2092. doi: 10.1038/s41598-022-06115-9.
The association and potential role of the protein hormone adiponectin in autoimmune diseases causing musculoskeletal disorders, including rheumatoid arthritis (RA), are controversial. Conflicting results may arise from the influences of confounding factors linked to genetic backgrounds, disease stage, disease-modifying anti-rheumatic drugs and patients' metabolic characteristics. Here, we examined serum level of adiponectin and its relationship with disease activity score 28 with erythrocytes sedimentation rate (DAS28[ESR]) and Sharp score in a treatment-naïve Han Chinese RA population. This cross-sectional study enrolled 125 RA patients. Serum level of total adiponectin was assessed by enzyme-linked immunosorbent assay (ELISA). Other important clinical and laboratory parameters were collected from the hospital database. DAS28(ESR) was calculated according to the equation previously published. Sharp score was evaluated based on hands radiographs by an independent radiologist. The correlation between serum adiponectin level and DAS28(ESR) or the Sharp score was investigated by univariate and multivariable linear regression analyses, respectively. Multiple imputation by chained equations was used to account for missing data. Univariate analyses showed a significant positive correlation between DAS28(ESR) and age or C-reactive protein (CRP) (both p = 0.003), while serum adiponectin level was negatively correlated with DAS28(ESR) (p = 0.015). The negative correlation between adiponectin level and DAS28(ESR) remained true in multivariable analyses adjusted for confounders. In addition, the univariate analyses revealed positive correlations of Sharp score to disease duration (p < 0.001), CRP (p = 0.023) and ESR (p < 0.001). In the multivariable model adjusted for confounders, adiponectin was negatively correlated with Sharp score (p = 0.013). In this single-institution cross-sectional study, serum adiponectin level in treatment-naive RA patients is negatively correlated with DAS28(ESR) and the Sharp score after adjustment for prominent identified confounders. Serum adiponectin may be potentially useful for assessing disease activity and radiographic progression of RA.
在引起肌肉骨骼疾病的自身免疫性疾病中，蛋白质激素脂联素的关联和潜在作用存在争议，包括类风湿关节炎（RA）。由于与遗传背景、疾病阶段、疾病修饰抗风湿药物和患者代谢特征相关的混杂因素的影响，可能会产生相互矛盾的结果。在这里，我们检查了未经治疗的汉族 RA 人群中血清脂联素水平及其与红细胞沉降率（DAS28[ESR]）和Sharp 评分的疾病活动评分 28（DAS28[ESR]）的关系。这项横断面研究纳入了 125 名 RA 患者。通过酶联免疫吸附测定（ELISA）评估总脂联素的血清水平。从医院数据库中收集其他重要的临床和实验室参数。根据先前发表的方程计算 DAS28（ESR）。Sharp 评分由独立放射科医生根据手部 X 光片进行评估。通过单变量和多变量线性回归分析分别研究血清脂联素水平与 DAS28（ESR）或 Sharp 评分之间的相关性。使用链式方程的多重插补来处理缺失数据。单变量分析显示 DAS28（ESR）与年龄或 C 反应蛋白（CRP）之间存在显著正相关（均 p<0.003），而血清脂联素水平与 DAS28（ESR）呈负相关（p=0.015）。在调整混杂因素后的多变量分析中，脂联素水平与 DAS28（ESR）之间的负相关仍然成立。此外，单变量分析显示 Sharp 评分与疾病持续时间（p<0.001）、CRP（p=0.023）和 ESR（p<0.001）呈正相关。在调整混杂因素的多变量模型中，脂联素与 Sharp 评分呈负相关（p=0.013）。在这项单机构横断面研究中，在调整了明显混杂因素后，未经治疗的 RA 患者的血清脂联素水平与 DAS28（ESR）和 Sharp 评分呈负相关。血清脂联素可能对评估 RA 的疾病活动和放射学进展具有潜在的作用。
