Bizzarro Matthew J, Hussain Naveed, Jonsson Baldvin, Feng Rui, Ment Laura R, Gruen Jeffrey R, Zhang Heping, Bhandari Vineet
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520-8064, USA.
Pediatrics. 2006 Nov;118(5):1858-63. doi: 10.1542/peds.2006-1088.
The goals were to isolate and to estimate the genetic susceptibility to retinopathy of prematurity.
A retrospective study (1994-2004) from 3 centers was performed with zygosity data for premature twins who were born at a gestational age of < or = 32 weeks and survived beyond a postmenstrual age of 36 weeks. Retinopathy of prematurity was diagnosed and staged by pediatric ophthalmologists at each center. Data analyses were performed with mixed-effects logistic regression analysis and latent variable probit modeling.
A total of 63 monozygotic and 137 dizygotic twin pairs were identified and analyzed. Data on gestational age, birth weight, gender, respiratory distress syndrome, retinopathy of prematurity, bronchopulmonary dysplasia, duration of ventilation and supplemental oxygen use, and length of stay were comparable between monozygotic and dizygotic twins. In the mixed-effects logistic regression analysis for retinopathy of prematurity, gestational age and duration of supplemental oxygen use were significant covariates. After controlling for known and unknown nongenetic factors, genetic factors accounted for 70.1% of the variance in liability for retinopathy of prematurity.
In addition to prematurity and environmental factors, there is a strong genetic predisposition to retinopathy of prematurity.
目标是分离并评估早产儿视网膜病变的遗传易感性。
对来自3个中心的一项回顾性研究（1994 - 2004年）进行了分析，该研究采用了孕周小于或等于32周且出生后月经龄超过36周的早产双胞胎的合子性数据。每个中心的儿科眼科医生对早产儿视网膜病变进行诊断和分期。数据分析采用混合效应逻辑回归分析和潜在变量概率模型。
共识别并分析了63对单卵双胞胎和137对双卵双胞胎。单卵双胞胎和双卵双胞胎在孕周、出生体重、性别、呼吸窘迫综合征、早产儿视网膜病变、支气管肺发育不良、通气时间和补充氧气使用情况以及住院时间等方面的数据具有可比性。在早产儿视网膜病变的混合效应逻辑回归分析中，孕周和补充氧气使用时间是显著的协变量。在控制了已知和未知的非遗传因素后，遗传因素占早产儿视网膜病变易感性变异的70.1%。
除了早产和环境因素外，早产儿视网膜病变存在很强的遗传易感性。
