哺乳动物的沉默调节蛋白——在生理学、衰老和热量限制中的新作用。

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

作者信息

Haigis Marcia C, Guarente Leonard P

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

Genes Dev. 2006 Nov 1;20(21):2913-21. doi: 10.1101/gad.1467506.

DOI:10.1101/gad.1467506

PMID:17079682

Abstract

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.

摘要

Sir2是一种依赖烟酰胺腺嘌呤二核苷酸（NAD）的去乙酰化酶，它在酵母、线虫和果蝇中连接着新陈代谢与寿命。哺乳动物含有酵母Sir2的七个同源物，即SIRT1 - 7。在这里，我们综述了最近的研究发现，这些发现证明了这些哺乳动物沉默调节蛋白作为生理、热量限制和衰老调节因子的作用。目前的研究结果加深了我们对沉默调节蛋白作为治疗主要衰老相关疾病潜在药理学靶点的理解。