Fukuda Takashi, Hasegawa Yoko, Hagimori Keiichi, Yamaguchi Yuichi, Masuma Rokuro, Tomoda Hiroshi, Omura Satoshi
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
J Antibiot (Tokyo). 2006 Aug;59(8):480-5. doi: 10.1038/ja.2006.67.
Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.
通过溶剂萃取、硅胶柱色谱和高效液相色谱法，从黑曲霉FKI-2342的培养液中分离出两种新的呋喃吡咯，分别命名为表面活性醇A和B。阐明了它们的结构，结果表明它们具有6-苄基-6H-呋喃并[2,3-b]吡咯的共同骨架。表面活性醇A和B增强了咪康唑对白色念珠菌的活性。表面活性醇还仅对稻瘟病菌表现出中等抗菌活性。
