由曲霉属FKI-2136菌株产生的茎菌素，是亚胺培南对耐甲氧西林金黄色葡萄球菌活性的新型增效剂。

Stemphones, novel potentiators of imipenem activity against methicillin-resistant staphylococcus aureus, produced by Aspergillus sp. FKI-2136.

作者信息

Koyama Nobuhiro, Nagahiro Tomoko, Yamaguchi Yuichi, Masuma Rokuro, Tomoda Hiroshi, Omura Satoshi

机构信息

School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

出版信息

J Antibiot (Tokyo). 2005 Nov;58(11):695-703. doi: 10.1038/ja.2005.95.

DOI:10.1038/ja.2005.95

PMID:16466023

Abstract

A fungal strain FKI-2136 identified as genus Aspergillus was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 fold by decreasing MIC value of imipenem from 16 microg/ml to 0.03 microg/ml.

摘要

一株被鉴定为曲霉属的真菌菌株FKI - 2136被发现能产生增强亚胺培南对耐甲氧西林金黄色葡萄球菌（MRSA）活性的增效剂。通过溶剂萃取、硅胶柱色谱和制备型高效液相色谱从该产生菌的发酵液中分离出两种新化合物，命名为茎孢菌素B和C，以及一种结构相关的已知化合物环根醌D。这些化合物具有共同的四环醌骨架。茎孢菌素C通过将亚胺培南的最低抑菌浓度（MIC）值从16微克/毫升降至0.03微克/毫升，使亚胺培南对MRSA的活性增强了512倍。