Hammad A M, Youssef H M, El-Arman M M
Department of Pediatrics, Mansoura Faculty of Medicine, Egypt.
Lupus. 2006;15(9):608-12. doi: 10.1177/0961203306071873.
Plasma and urinary (latent and active) TGF-beta1 levels were assessed in 32 children with active lupus and compared to 15 healthy controls of matched age and sex. Plasma latent and active TGF-beta1 levels in children with active disease were significantly lower than controls (P = 0.004 and P < 0.001 respectively). Plasma active TGF-beta1 correlated negatively with Systemic Lupus Erythematosus Disease Activity Index (r = -0.38, P = 0.03). On the contrary, urinary latent and active TGF-beta1 levels in children with active disease were significantly higher than controls (P < 0.001 and P = 0.003 respectively). Urinary active TGF-beta1 levels correlated positively with Anti-ds DNA titre (r = 0.42, P = 0.015) and negatively with serum C3 levels (r = -0.48, P = 0.005). Patients with symptomatic nephritis had significantly elevated urinary active TGF-beta1 levels in comparison to those with silent nephritis (P = 0.008). From this data we conclude that lowered plasma TGF-beta1 levels may be a feature of systemic immune dysfunction in children with active lupus while increased renal production of active TGF-beta1 seems to have a role in the clinical presentation of lupus nephritis.
对32名活动性狼疮患儿的血浆和尿液（潜伏性和活性）转化生长因子β1（TGF-β1）水平进行了评估，并与15名年龄和性别匹配的健康对照者进行比较。活动性疾病患儿的血浆潜伏性和活性TGF-β1水平显著低于对照组（分别为P = 0.004和P < 0.001）。血浆活性TGF-β1与系统性红斑狼疮疾病活动指数呈负相关（r = -0.38，P = 0.03）。相反，活动性疾病患儿的尿液潜伏性和活性TGF-β1水平显著高于对照组（分别为P < 0.001和P = 0.003）。尿液活性TGF-β1水平与抗双链DNA滴度呈正相关（r = 0.42，P = 0.015），与血清C3水平呈负相关（r = -0.48，P = 0.005）。与无症状性肾炎患儿相比，有症状性肾炎的患儿尿液活性TGF-β1水平显著升高（P = 0.008）。根据这些数据，我们得出结论，血浆TGF-β1水平降低可能是活动性狼疮患儿全身免疫功能障碍的一个特征，而肾脏活性TGF-β1产生增加似乎在狼疮性肾炎的临床表现中起作用。
