• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

造血生长因子对c-kit信使核糖核酸及蛋白质的调节作用

Modulation of c-kit mRNA and protein by hemopoietic growth factors.

作者信息

Welham M J, Schrader J W

机构信息

Biomedical Research Centre, University of British Columbia, Vancouver, Canada.

出版信息

Mol Cell Biol. 1991 May;11(5):2901-4. doi: 10.1128/mcb.11.5.2901-2904.1991.

DOI:10.1128/mcb.11.5.2901-2904.1991
PMID:1708097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC360082/
Abstract

We examined the effects of various hemopoietins on c-kit mRNA and protein expression. Interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and erythropoietin, but not IL-4, down-regulated levels of c-kit mRNA expressed by mast cells and stem cell progenitors. The effect of IL-3 was dominant and independent of cell growth or viability and was paralleled by reduced expression in c-kit protein. These observations indicate that regulation of c-kit expression is closely interlinked with the molecular mechanisms triggered by erythropoietin, IL-3, and granulocyte-macrophage colony-stimulating factor.

摘要

我们研究了各种造血生长因子对c-kit信使核糖核酸（mRNA）和蛋白质表达的影响。白细胞介素-3（IL-3）、粒细胞-巨噬细胞集落刺激因子和促红细胞生成素可下调肥大细胞和干细胞祖细胞表达的c-kit mRNA水平，但IL-4无此作用。IL-3的作用占主导地位，且与细胞生长或活力无关，同时c-kit蛋白表达也相应降低。这些观察结果表明，c-kit表达的调控与促红细胞生成素、IL-3和粒细胞-巨噬细胞集落刺激因子触发的分子机制密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/14688552d215/molcellb00139-0579-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/b9feb474533a/molcellb00139-0578-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/fb7014fb0d25/molcellb00139-0578-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/348772fadf8a/molcellb00139-0578-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/bde9b12e1920/molcellb00139-0579-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/14688552d215/molcellb00139-0579-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/b9feb474533a/molcellb00139-0578-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/fb7014fb0d25/molcellb00139-0578-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/348772fadf8a/molcellb00139-0578-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/bde9b12e1920/molcellb00139-0579-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a8/360082/14688552d215/molcellb00139-0579-b.jpg

相似文献

1
Modulation of c-kit mRNA and protein by hemopoietic growth factors.造血生长因子对c-kit信使核糖核酸及蛋白质的调节作用
Mol Cell Biol. 1991 May;11(5):2901-4. doi: 10.1128/mcb.11.5.2901-2904.1991.
2
Expression and function of c-kit in hemopoietic progenitor cells.c-kit在造血祖细胞中的表达及功能
J Exp Med. 1991 Jul 1;174(1):63-71. doi: 10.1084/jem.174.1.63.
3
In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.c-kit和Sca-1阳性小鼠造血细胞的体内和体外干细胞功能。
Blood. 1992 Dec 15;80(12):3044-50.
4
Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.Raf-1蛋白是造血细胞生长因子诱导增殖所必需的。
J Exp Med. 1995 Jun 1;181(6):2189-99. doi: 10.1084/jem.181.6.2189.
5
Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors.Flt3配体对人类造血的多层次影响：假定干细胞的扩增及粒单核祖细胞/单核前体细胞的增殖。
Blood. 1995 Sep 1;86(5):1661-70.
6
gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells.gp130和c-Kit信号协同作用以实现人原始造血祖细胞的体外扩增。
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2859-63. doi: 10.1073/pnas.92.7.2859.
7
Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.多能造血干细胞含有高水平的c-kit、GATA-2、p45 NF-E2和c-myb的mRNA，而c-fms以及粒细胞集落刺激因子和白细胞介素5和7的受体的mRNA水平较低或没有。
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4601-5. doi: 10.1073/pnas.92.10.4601.
8
In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia.干细胞因子对获得性重型再生障碍性贫血集落生长的体外效应
Stem Cells. 1993 Jul;11 Suppl 2:175-9. doi: 10.1002/stem.5530110828.
9
Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit.早期的CD34高表达细胞可分为两类：一类是KIT高表达细胞，其中转化生长因子-β（TGF-β）可下调c-kit；另一类是KIT低表达细胞，其中抗TGF-β可上调c-kit。
Blood. 1995 Sep 1;86(5):1729-35.
10
Mast cell growth factor (c-kit ligand) restores growth of multipotent progenitors in myelodysplastic syndrome.肥大细胞生长因子（c-kit配体）可恢复骨髓增生异常综合征中多能祖细胞的生长。
Leukemia. 1994 May;8(5):827-32.

引用本文的文献

1
Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy.系统性肥大细胞增多症的分子生物学新进展：对诊断、预后和治疗的影响。
Int J Mol Sci. 2020 Jun 2;21(11):3987. doi: 10.3390/ijms21113987.
2
GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells.粒细胞-巨噬细胞集落刺激因子抑制骨髓来源树突状细胞的c-Kit和干细胞因子表达。
Front Immunol. 2017 Feb 16;8:147. doi: 10.3389/fimmu.2017.00147. eCollection 2017.
3
Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin.

本文引用的文献

1
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.对培养的小鼠胚胎细胞生长及其发育成既定细胞系的定量研究。
J Cell Biol. 1963 May;17(2):299-313. doi: 10.1083/jcb.17.2.299.
2
A transplantable mast-cell neoplasm in the mouse.一种可移植的小鼠肥大细胞瘤。
J Natl Cancer Inst. 1957 Apr;18(4):587-601.
3
Strategies for the analysis of accessory-cell function: the in vitro cloning and characterization of the P cell.辅助细胞功能分析策略：P细胞的体外克隆与特性研究
过表达促红细胞生成素的小鼠十二指肠黏膜中的肥大细胞和巨噬细胞。
J Anat. 2009 Nov;215(5):548-54. doi: 10.1111/j.1469-7580.2009.01131.x. Epub 2009 Aug 18.
4
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts.有丝分裂原性生长因子和转化癌基因对小鼠3T3成纤维细胞中血小板衍生生长因子β受体表达的抑制作用
Mol Cell Biol. 1995 Mar;15(3):1244-53. doi: 10.1128/MCB.15.3.1244.
5
Phosphatidylinositol 3'-kinase associates with p145c-kit as part of a cell type characteristic multimeric signalling complex.磷脂酰肌醇3'-激酶与p145c-kit结合，作为细胞类型特征性多聚体信号复合物的一部分。
EMBO J. 1993 Oct;12(10):3817-26. doi: 10.1002/j.1460-2075.1993.tb06060.x.
6
The effect of interleukin-4 with or without mast cell growth factor on peripheral blood granulocyte-macrophage colony-forming cells in healthy controls and in myeloproliferative disorders.白细胞介素-4联合或不联合肥大细胞生长因子对健康对照者及骨髓增殖性疾病患者外周血粒细胞-巨噬细胞集落形成细胞的影响。
Ann Hematol. 1995 Apr;70(4):203-7. doi: 10.1007/BF01700376.
7
Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.功能性c-kit受体的表达挽救了W突变肥大细胞的基因缺陷。
EMBO J. 1991 Dec;10(12):3683-91. doi: 10.1002/j.1460-2075.1991.tb04936.x.
8
A GM-colony-stimulating factor (CSF) activated ribonuclease system transregulates M-CSF receptor expression in the murine FDC-P1/MAC myeloid cell line.粒细胞-巨噬细胞集落刺激因子（CSF）激活的核糖核酸酶系统可反式调节小鼠FDC-P1/MAC髓系细胞系中巨噬细胞集落刺激因子（M-CSF）受体的表达。
Mol Biol Cell. 1992 May;3(5):535-44. doi: 10.1091/mbc.3.5.535.
9
c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.c-Kit激酶在正常人类黑素细胞中响应肥大细胞生长因子时诱导一系列蛋白质酪氨酸磷酸化，并刺激丝裂原活化蛋白激酶，但在黑色素瘤中表达下调。
Mol Biol Cell. 1992 Feb;3(2):197-209. doi: 10.1091/mbc.3.2.197.
10
Role of the KIT protooncogene in normal and malignant human hematopoiesis.KIT原癌基因在正常和恶性人类造血中的作用。
Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1710-4. doi: 10.1073/pnas.89.5.1710.
Immunol Rev. 1980;53:61-85. doi: 10.1111/j.1600-065x.1980.tb01040.x.
4
The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.持久（P）细胞：组胺含量、受T细胞衍生因子的调节、起源于骨髓前体细胞以及与肥大细胞的关系。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):323-7. doi: 10.1073/pnas.78.1.323.
5
Growth of factor-dependent hemopoietic precursor cell lines.因子依赖性造血前体细胞系的生长
J Exp Med. 1980 Oct 1;152(4):1036-47. doi: 10.1084/jem.152.4.1036.
6
Autogenous production of a hemopoietic growth factor, persisting-cell-stimulating factor, as a mechanism for transformation of bone marrow-derived cells.作为骨髓来源细胞转化机制的造血生长因子（持久细胞刺激因子）的自体产生。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6892-6. doi: 10.1073/pnas.80.22.6892.
7
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.一种将DNA限制性内切酶片段放射性标记至高比活度的技术。
Anal Biochem. 1983 Jul 1;132(1):6-13. doi: 10.1016/0003-2697(83)90418-9.
8
Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization.丝裂原激活的牛淋巴细胞中蛋白质合成的调控。肌动蛋白特异性和总mRNA积累与利用的分析。
J Biol Chem. 1983 Oct 25;258(20):12153-62.
9
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
10
Biochemical and biological properties of interleukin-3: a lymphokine mediating the differentiation of a lineage of cells that includes prothymocytes and mastlike cells.白细胞介素-3的生化及生物学特性：一种介导包括前胸腺细胞和类肥大细胞在内的细胞系分化的淋巴因子。
Contemp Top Mol Immunol. 1985;10:93-119. doi: 10.1007/978-1-4684-4838-2_4.