Galanopoulou P, Giannacopoulos G, Theophanopoulos C, Couvaris M K, Varonos D
Department of Pharmacology, Medical School, University of Athens, Greece.
Pharmacol Biochem Behav. 1990 Nov;37(3):461-4. doi: 10.1016/0091-3057(90)90013-8.
The effects of pizotifen on protein and carbohydrate self-selection in rats over a seven-day period, and on 5-HT turnover was studied. Four groups of male Wistar rats were individually caged and ad lib fed with a standard (SD) and (50%) carbohydrate-enriched diet (CED), sweet (diet group I) or not (diet group II). Food intake was measured daily 4 hr after IP injection of pizotifen (2.5 mg/kg) or vehicle. 5-HT and 5-HIAA in the hypothalamus (Hy), striatum (St) and hippocampus (Hi) were assayed on the 8th day of the experiment. Pizotifen increased the consumption of SD. The absolute intake of CED remained totally and daily unchanged, while the percentage proportion was reduced. Total food intake was increased by the drug which seemed to affect the proportion rather than the absolute amounts of carbohydrate and protein consumed. This effect was independent of the carbohydrate taste. There was a decrease of 5-HT levels in the Hi, while 5-HIAA/5-HT ratio was increased in the Hy and in the Hi of animals that consumed sweet carbohydrate. The above data suggest a role of pizotifen on 5-HT central metabolism and diet selection and support the view that changes of 5-HT metabolism in the Hy and Hi are responsible for protein selection and the regulation of SD/CED ratio, but they cannot explain drug's effect on total food intake.
研究了苯噻啶对大鼠7天内蛋白质和碳水化合物自选情况以及对5-羟色胺（5-HT）代谢周转的影响。将四组雄性Wistar大鼠单独关在笼中，随意喂食标准饮食（SD）和（50%）富含碳水化合物的饮食（CED），一种是甜的（饮食组I），另一种不是（饮食组II）。在腹腔注射苯噻啶（2.5毫克/千克）或赋形剂4小时后，每天测量食物摄入量。在实验的第8天，测定下丘脑（Hy）、纹状体（St）和海马体（Hi）中的5-HT和5-羟吲哚乙酸（5-HIAA）。苯噻啶增加了标准饮食的消耗量。富含碳水化合物饮食的绝对摄入量每天完全保持不变，但其百分比比例降低。药物增加了总食物摄入量，这似乎影响了所消耗碳水化合物和蛋白质的比例而非绝对量。这种作用与碳水化合物的味道无关。海马体中的5-HT水平降低，而在食用甜碳水化合物的动物的下丘脑和海马体中，5-HIAA/5-HT比值增加。上述数据表明苯噻啶在5-HT中枢代谢和饮食选择中起作用，并支持以下观点：下丘脑和海马体中5-HT代谢的变化负责蛋白质选择和标准饮食/富含碳水化合物饮食比例的调节，但它们无法解释药物对总食物摄入量的影响。
