Schweiger U, Broocks A, Tuschl R J, Pirke K M
Division of Psychoneuroendocrinology, Max-Planck-Institut für Psychiatrie, München, Federal Republic of Germany.
J Neural Transm. 1989;77(2-3):131-9. doi: 10.1007/BF01248926.
Serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) were determined in seven brain regions of semistarved and control male rats. After semistarvation on a high carbohydrate diet serotonin turnover, as indicated by 5-HIAA/5-HT ratio, was increased in the total brain and several regions both three and 24 hours after the last meal. In contrast, after semistarvation on a high-protein diet serotonin turnover was decreased three hours after ingestion of the final meal, but increased 24 hours thereafter. Compulsary running wheel activity for one hour did not influence diet induce changes in serotonin turnover. Alterations in plasma corticosterone during semistarvation were not related to changes in central serotonin turnover. Data suggest that the interaction of caloric restriction and diet composition determines serotonin turnover during semi-starvation.
测定了半饥饿和对照雄性大鼠七个脑区中的血清素（5-羟色胺，5-HT）和5-羟吲哚乙酸（5-HIAA）。在高碳水化合物饮食的半饥饿状态下，如5-HIAA/5-HT比值所示，血清素周转率在最后一餐3小时和24小时后，全脑及几个脑区均升高。相比之下，在高蛋白饮食的半饥饿状态下，血清素周转率在摄入最后一餐3小时后降低，但在之后的24小时升高。强制进行1小时跑步轮活动不影响饮食诱导的血清素周转率变化。半饥饿期间血浆皮质酮的变化与中枢血清素周转率的变化无关。数据表明，热量限制和饮食组成的相互作用决定了半饥饿期间的血清素周转率。
