Peters J C, Bellissimo D B, Harper A E
Physiol Behav. 1984 Feb;32(2):253-9. doi: 10.1016/0031-9384(84)90138-0.
Nutritional studies on rats given a choice between two diets differing in protein content have led to the proposal that brain 5-HT content regulates protein intake [2]. Pharmacologic studies under similar conditions of dietary self-selection suggest that brain 5-HT controls carbohydrate intake [41]. We tested the effect of elevating brain 5-HT via tryptophan injection (100 mg/kg) on short-term food intake and selection by rats choosing between two diets differing in protein and carbohydrate content. Under these conditions neither total food intake nor protein and carbohydrate selection were affected despite increases of 50% in brain concentrations of 5-HT and 5-HIAA. The effect of Trp administration was selective to serotonin metabolism as brain concentrations of NE, DA and DOPAC were not affected. These results suggest that alterations in brain 5-HT content which may occur following meal ingestion may not be of physiological importance in regulating nutrient intake and selection.
对可在两种蛋白质含量不同的饮食之间进行选择的大鼠开展的营养研究，引发了如下提议：即大脑5-羟色胺（5-HT）含量调节蛋白质摄入量[2]。在类似的饮食自我选择条件下开展的药理学研究表明，大脑5-HT控制碳水化合物摄入量[41]。我们通过注射色氨酸（100毫克/千克）提高大脑5-HT水平，测试其对大鼠短期食物摄入量以及在两种蛋白质和碳水化合物含量不同的饮食之间进行选择的影响。在这些条件下，尽管大脑中5-HT和5-羟吲哚乙酸（5-HIAA）的浓度增加了50%，但总食物摄入量以及蛋白质和碳水化合物的选择均未受到影响。色氨酸给药的作用对血清素代谢具有选择性，因为大脑中去甲肾上腺素（NE）、多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）的浓度未受影响。这些结果表明，进食后可能发生的大脑5-HT含量变化，在调节营养物质摄入和选择方面可能不具有生理重要性。
