Wang Zhiwei, Hou Zhonghuai, Xin Houwen, Zhang Zhizhou
Teda Bio-X Research Center, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, The 13th Avenue of Teda, Tianjin, PR China, 300457.
Biophys Chem. 2007 Feb;125(2-3):281-5. doi: 10.1016/j.bpc.2006.09.006. Epub 2006 Sep 14.
Based on a genetic bistable switch model coupled with a gene oscillator model, we have constructed a mesoscopic stochastic model for the coupled synthetic gene network, and studied how internal noise would influence the oscillation of such a system. We found that the state-to-state transitions can occur if the internal noise is taken into account, and the performance of resulting oscillation can reach a maximum in a certain internal noise level, which indicates the occurrence of internal noise stochastic resonance (SR) and makes the coupled gene network work as a stochastic resonator. The potential role of such an effect on gene expression systems is also discussed.
基于一个基因双稳态开关模型与一个基因振荡器模型相结合，我们构建了一个用于耦合合成基因网络的介观随机模型，并研究了内部噪声如何影响这样一个系统的振荡。我们发现，如果考虑内部噪声，状态到状态的转变就会发生，并且所产生振荡的性能在一定的内部噪声水平下可以达到最大值，这表明发生了内部噪声随机共振（SR），并使耦合基因网络起到随机谐振器的作用。还讨论了这种效应在基因表达系统中的潜在作用。
