Berry M R, Scott J
Department of Clinical Dental Sciences, School of Dentistry, University of Liverpool, U.K.
Alcohol Alcohol. 1990;25(5):523-31.
Male rats were maintained on a regimen of twice daily intragastric administration of ethanol or a calorifically equivalent sucrose solution for thirty days. A second control group received no intragastric solution and all groups received chow and water ad libitum. Parotid saliva elicited by pilocarpine was collected by unilateral duct cannulation. The parotid flow rate over the initial post-stimulatory five minute period was raised by 44% in ethanol-dosed rats and the salivary sodium concentration was also raised, in line with higher flow rate. There were no histopathological changes related to ethanol or sucrose dosing, but stereological analysis showed a 64% increase in the proportional volume of intralobular vascular tissue in ethanol-dosed rats. These quantified histological findings suggest that parotid intralobular haemodynamics may be altered after chronic ethanol-dosing and this may contribute to the hypersecretory response exhibited by the ethanol-dosed rats.
雄性大鼠接受为期三十天的每日两次乙醇或热量相当的蔗糖溶液灌胃给药方案。第二个对照组不接受灌胃溶液，所有组均可自由摄取食物和水。通过单侧导管插管收集毛果芸香碱引发的腮腺唾液。在乙醇给药的大鼠中，刺激后最初五分钟内腮腺流速提高了44%，唾液钠浓度也随着流速升高而升高。与乙醇或蔗糖给药无关的组织病理学变化，但体视学分析显示，乙醇给药大鼠的小叶内血管组织比例体积增加了64%。这些定量的组织学结果表明，慢性乙醇给药后腮腺小叶内血流动力学可能发生改变，这可能导致乙醇给药大鼠出现高分泌反应。
