Lambert Sarah M, Masson Puneet, Fisch Harry
Columbia University College of Physicians and Surgeons, Department of Urology, Columbia University Medical Center of New York Presbyterian Hospital, 944 Park Ave, New York, NY 10028, USA.
World J Urol. 2006 Dec;24(6):611-7. doi: 10.1007/s00345-006-0130-y.
Do men have biological clocks that affect their hormone levels, fertility, and the genetic quality of their sperm? Women can no longer be viewed as solely responsible for age-related fertility and genetic problems. The effects of andropause and advanced paternal age on fertility and offspring are still under investigation. Further research is needed to fully characterize the associated risks and to treat the underlying abnormalities. A better understanding of the cellular and biochemical mechanisms of "gonadal" aging is important in order to determine safe, effective ways to delay this process and "rewind" the male biological clock. The benefits may include decreasing the potential for adverse genetic consequences in offspring, improvement in the sexual and reproductive health of aging males, and increase a woman's chance of having healthy children by correcting defects in the male reproductive system.
男性是否拥有影响其激素水平、生育能力以及精子基因质量的生物钟?女性不应再被视为与年龄相关的生育和基因问题的唯一责任方。男性更年期和高龄父亲对生育能力及后代的影响仍在研究之中。需要进一步开展研究以全面描述相关风险并治疗潜在的异常情况。更好地理解“性腺”衰老的细胞和生化机制对于确定安全、有效的方法来延缓这一过程以及“重置”男性生物钟至关重要。其益处可能包括降低后代出现不良基因后果的可能性、改善老年男性的性健康和生殖健康,以及通过纠正男性生殖系统缺陷来增加女性生育健康子女的机会。