Kovac Jason R, Addai Josephine, Smith Ryan P, Coward Robert M, Lamb Dolores J, Lipshultz Larry I
Asian J Androl. 2013 Nov;15(6):723-8. doi: 10.1038/aja.2013.92. Epub 2013 Aug 5.
Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.
在过去几十年中，现代社会的压力和期望导致夫妻倾向于推迟受孕。虽然女性在35岁后期卵母细胞生成显著减少，但年龄对精子发生的影响描述较少。虽然男性生育孩子的年龄没有已知限制，但父亲年龄偏大的影响尚未完全了解。本综述总结了关于父亲年龄偏大的当前知识状态及其对精液质量、生殖成功率和后代健康的影响。本综述将作为医生为男性提供咨询的指南，内容涉及推迟生育的决定以及晚年受孕所涉及的风险。
