Noval Susana, Contreras Inés, Rebolleda Gema, Muñoz-Negrete Francisco J
Department of Ophthalmology, Ramón y Cajal Hospital, Madrid, Spain.
Acta Ophthalmol Scand. 2006 Dec;84(6):790-4. doi: 10.1111/j.1600-0420.2006.00724.x.
To evaluate the usefulness of optical coherence tomography (OCT) for follow-up of optic neuritis (ON) compared with subjective visual function tests.
Twelve patients with ON underwent a complete ophthalmological evaluation at initial diagnosis, including best corrected visual acuity (VA), visual fields testing and OCT examination. These examinations were repeated periodically over 6 months. Retinal nerve fibre layer (RNFL) thickness evolution was analysed and correlated with VA and visual field mean deviation.
Six months after ON, mean RNFL in the affected eye decreased significantly compared with that in the fellow eye (24.54%). A significant correlation was found between RNFL thinning and final VA (r = 0.807, p = 0.005), with a 1-line drop in VA for every 5.4-micro m decrease. All patients with an altered visual field had an abnormal RNFL value; of the seven patients with normal visual fields, 57% had an abnormal RNFL value (p < 5%).
Optical coherence tomography can detect axonal damage as early as the third month after an isolated initial episode of ON, even in the presence of normal visual fields. Mean RNFL thinning is correlated with final VA.
与主观视觉功能测试相比，评估光学相干断层扫描（OCT）对视神经炎（ON）随访的有用性。
12例视神经炎患者在初诊时接受了全面的眼科评估，包括最佳矫正视力（VA）、视野测试和OCT检查。这些检查在6个月内定期重复进行。分析视网膜神经纤维层（RNFL）厚度的变化，并将其与视力和视野平均偏差进行关联。
视神经炎发生6个月后，患眼的平均RNFL与对侧眼相比显著降低（24.54%）。RNFL变薄与最终视力之间存在显著相关性（r = 0.807，p = 0.005），RNFL每减少5.4微米，视力下降1行。所有视野改变的患者RNFL值均异常；在7例视野正常的患者中，57%的患者RNFL值异常（p < 5%）。
光学相干断层扫描即使在视野正常的情况下，也能在孤立的首次视神经炎发作后第三个月就检测到轴突损伤。平均RNFL变薄与最终视力相关。
