Matunis Michael J, Zhang Xiang-Dong, Ellis Nathan A
Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Dev Cell. 2006 Nov;11(5):596-7. doi: 10.1016/j.devcel.2006.10.011.
Two articles in a recent issue of Molecular Cell (Shen et al., 2006; Lin et al., 2006) demonstrate that noncovalent interactions between the SUMO moieties of SUMO-modified PML, and SUMO binding motifs on PML and other PML nuclear-body-associated proteins, affect the assembly of PML nuclear bodies and the recruitment of proteins in and out of these subnuclear structures.
最近一期《分子细胞》杂志上的两篇文章(Shen等人,2006年;Lin等人,2006年)表明,SUMO修饰的PML的SUMO部分之间的非共价相互作用,以及PML和其他与PML核体相关蛋白上的SUMO结合基序,会影响PML核体的组装以及蛋白质进出这些亚核结构的募集。