骨骼与能量稳态之间的关联：瘦素对骨量的调节

Convergence between bone and energy homeostases: leptin regulation of bone mass.

作者信息

Karsenty Gerard

机构信息

Department of Genetics and Development, Columbia University, New York, New York 10032, USA.

出版信息

Cell Metab. 2006 Nov;4(5):341-8. doi: 10.1016/j.cmet.2006.10.008.

DOI:10.1016/j.cmet.2006.10.008

PMID:17084709

Abstract

The observation that obesity protects from osteoporosis suggested that energy metabolism and bone mass could be regulated by the same hormones. Testing this hypothesis revealed that leptin regulates bone mass through a hypothalamic relay and using two neural mediators, the sympathetic tone and CART, both acting on one cell type the osteoblast. This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications.

摘要

肥胖可预防骨质疏松这一观察结果表明，能量代谢和骨量可能受相同激素的调节。对这一假说的验证显示，瘦素通过下丘脑传导途径调节骨量，并利用两种神经介质，即交感神经张力和可卡因-安非他明调节转录肽（CART），二者均作用于同一细胞类型——成骨细胞。本文综述了这种调节的遗传和分子基础，并讨论了其潜在的临床意义。