Takeda Shu, Karsenty Gerard
Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Bone. 2008 May;42(5):837-40. doi: 10.1016/j.bone.2008.01.005. Epub 2008 Jan 26.
The discovery that leptin regulates bone mass through a central relay generated a lot of interest and raised the question about the identity of the neural mediator linking the brain to the skeleton. In this review we discuss the genetic, neuroanatomical and physiological evidence identifying the sympathetic tone as one of the mediator of leptin regulation of bone mass. We also discussed the antagonistic role played by two beta adrenergic receptors in this regulation and the relevance of these results obtained through studies of model organisms to human physiology and pathology.
瘦素通过中枢传导调节骨量这一发现引发了广泛关注，并提出了关于连接大脑与骨骼的神经介质身份的问题。在本综述中，我们讨论了遗传学、神经解剖学和生理学证据，这些证据表明交感神经张力是瘦素调节骨量的介质之一。我们还讨论了两种β-肾上腺素能受体在这种调节中所起的拮抗作用，以及通过模式生物研究获得的这些结果与人类生理和病理的相关性。
