年龄相关性肌肉骨骼疾病中的脂质代谢：对肌肉减少症和骨质疏松症的见解
Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis.
作者信息
Lal Shivum, Gunji Shreya, Ahluwalia Pankaj, Kolhe Ravindra, Bollag Wendy B, Hill William D, McGee-Lawrence Meghan E, Isales Carlos M, Fulzele Sadanand
机构信息
Department of Medicine, Augusta University, Augusta, GA, USA.
Department of Pathology, Augusta University, Augusta, GA, USA.
出版信息
BMC Biol. 2025 Aug 22;23(1):265. doi: 10.1186/s12915-025-02383-9.
Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.
肌肉骨骼疾病（MSDs），尤其是肌肉减少症和骨质疏松症，对老年人有深远影响。本综述探讨了脂质代谢在与年龄相关的肌肉骨骼疾病病理生理学中的作用，重点关注脂肪酸摄取、脂质信号传导以及肌肉退化中的脂毒性。它还讨论了脂质介导的破骨细胞、成骨细胞和骨重塑调节，强调与年龄相关的代谢变化会加剧骨质流失。此外，还讨论了针对肌肉骨骼疾病治疗的脂质途径的新兴治疗策略。本综述整合了肌肉和骨骼脂质代谢的最新研究结果，以加深对肌肉骨骼疾病中脂质失调的理解，并探索潜在的代谢干预策略。
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