de Mos M, de Bruijn A G J, Huygen F J P M, Dieleman J P, Stricker B H Ch, Sturkenboom M C J M
Erasmus Medical Center, Pharmaco-epidemiology Unit, Department of Medical Informatics, PO BOX 2040, 3000 CA Rotterdam, The Netherlands.
Pain. 2007 May;129(1-2):12-20. doi: 10.1016/j.pain.2006.09.008. Epub 2006 Nov 7.
The complex regional pain syndrome (CRPS) is a painful disorder that can occur in an extremity after any type of injury, or even spontaneously. Data on the incidence of CRPS are scarce and mostly hospital based. Therefore the size of the problem and its burden on health care and society are unknown. The objective of the present study was to estimate the incidence of CRPS in the general population. A retrospective cohort study was conducted during 1996-2005 in the Integrated Primary Care Information (IPCI) project, a general practice research database with electronic patient record data from 600,000 patients throughout The Netherlands. Potential CRPS cases were identified by a sensitive search algorithm including synonyms and abbreviations for CRPS. Subsequently, cases were validated by electronic record review, supplemented with original specialist letters and information from an enquiry of general practitioners. The estimated overall incidence rate of CRPS was 26.2 per 100,000 person years (95% CI: 23.0-29.7). Females were affected at least three times more often than males (ratio: 3.4). The highest incidence occurred in females in the age category of 61-70 years. The upper extremity was affected more frequently than the lower extremity and a fracture was the most common precipitating event (44%). The observed incidence rate of CRPS is more as four times higher than the incidence rate observed in the only other population-based study, performed in Olmsted County, USA. Postmenopausal woman appeared to be at the highest risk for the development of CRPS.
复杂区域疼痛综合征（CRPS）是一种疼痛性疾病，可在任何类型的损伤后出现在肢体上，甚至可自发出现。关于CRPS发病率的数据稀缺，且大多基于医院。因此，该问题的规模及其对医疗保健和社会的负担尚不清楚。本研究的目的是估计普通人群中CRPS的发病率。1996年至2005年期间，在综合初级保健信息（IPCI）项目中进行了一项回顾性队列研究，该项目是一个全科医学研究数据库，包含来自荷兰全国60万名患者的电子病历数据。通过一种敏感的搜索算法识别潜在的CRPS病例，该算法包括CRPS的同义词和缩写。随后，通过电子病历审查对病例进行验证，并辅以原始专科医生信件和来自全科医生询问的信息。CRPS的估计总体发病率为每10万人年26.2例（95%可信区间：23.0 - 29.7）。女性受影响的频率至少是男性的三倍（比例：3.4）。最高发病率出现在61 - 70岁年龄组的女性中。上肢比下肢更常受累，骨折是最常见的促发事件（44%）。观察到的CRPS发病率比在美国奥尔姆斯特德县进行的另一项仅基于人群的研究所观察到的发病率高出四倍多。绝经后女性似乎是发生CRPS的最高风险人群。
