Jovanovic Hristina, Cerin Asta, Karlsson Per, Lundberg Johan, Halldin Christer, Nordström Anna-Lena
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden.
Psychiatry Res. 2006 Dec 1;148(2-3):185-93. doi: 10.1016/j.pscychresns.2006.05.002. Epub 2006 Nov 7.
The cause of premenstrual dysphoric disorder (PMDD) is largely unknown. It has been hypothesized that normal ovarian function triggers PMDD-related biochemical events within the brain and that serotonin plays an important role. In the present study, positron emission tomography (PET) and [carbonyl-(11)C]WAY-100635 were used to examine serotonin 5-HT(1A) receptors in a control group of women and in a group of women with PMDD. Two PET examinations were performed in each subject, one before (follicular phase) and one after ovulation (luteal phase). Each subject's menstrual cycle was confirmed by ultrasonography of the ovaries as well as with hormone levels in blood and urine. The 5-HT(1A) binding potential was measured in six regions of interest and calculated according to the simplified reference tissue model. In the raphe nuclei, the 5-HT(1A) binding potential changed from the follicular to the luteal phase of the menstrual cycle in asymptomatic controls. In women with PMDD, the observed change between phases was significantly smaller. The results are in concordance with previously reported challenge studies of 5-HT(1A) receptor-mediated effects indicating different serotonergic responses between women with PMDD and controls. The study principally provides new support, in vivo, for a serotonergic dysregulation in women with PMDD.
经前烦躁障碍（PMDD）的病因很大程度上尚不清楚。据推测，正常的卵巢功能会触发大脑内与PMDD相关的生化事件，且血清素起着重要作用。在本研究中，正电子发射断层扫描（PET）和[羰基-（11）C]WAY-100635被用于检查一组对照女性和一组患有PMDD的女性的血清素5-HT（1A）受体。对每个受试者进行了两次PET检查，一次在排卵前（卵泡期），一次在排卵后（黄体期）。通过卵巢超声检查以及血液和尿液中的激素水平确认了每个受试者的月经周期。在六个感兴趣区域测量5-HT（1A）结合潜能，并根据简化参考组织模型进行计算。在中缝核中，无症状对照组月经周期从卵泡期到黄体期的5-HT（1A）结合潜能发生了变化。在患有PMDD的女性中，观察到的不同阶段之间的变化明显较小。这些结果与先前报道的关于5-HT（1A）受体介导效应的激发研究一致，表明患有PMDD的女性和对照组之间存在不同的血清素能反应。该研究主要在体内为患有PMDD的女性血清素调节异常提供了新的证据。
