Svenningsson Per, Greengard Paul
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Curr Opin Pharmacol. 2007 Feb;7(1):27-32. doi: 10.1016/j.coph.2006.10.001. Epub 2006 Nov 7.
p11 (S100A10) is a member of the S100 protein family and forms a heterotetrameric complex with annexin 2. p11 has also been found to interact with a diverse set of proteins that includes several ion channels and the serotonin 5-HT1B receptor. Several factors such as dexamethasone, growth factors, nitric oxide and antidepressant therapies regulate the expression of p11. Furthermore, studies using mutant mouse models, RNA interference and antisense constructs have implicated p11 in several biological processes; in particular, there is evidence that p11 is involved in the pathophysiology underlying nociception and depression-like states.
p11（S100A10）是S100蛋白家族的成员，与膜联蛋白2形成异源四聚体复合物。人们还发现p11能与多种蛋白质相互作用，这些蛋白质包括几种离子通道和5-羟色胺5-HT1B受体。地塞米松、生长因子、一氧化氮和抗抑郁疗法等多种因素可调节p11的表达。此外，利用突变小鼠模型、RNA干扰和反义构建体进行的研究表明p11参与了多个生物学过程；特别是，有证据表明p11参与了伤害感受和抑郁样状态的病理生理学过程。
