Department of Clinical Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.
Trends Pharmacol Sci. 2020 Jul;41(7):487-497. doi: 10.1016/j.tips.2020.04.004. Epub 2020 May 14.
p11 (S100A10, annexin II light chain, calpactin I light chain) is a multifunctional protein that forms a heterotetrameric complex with Annexin A2, particularly at cell membranes. p11, alone or together with Annexin A2, interacts with several ion channels and receptors and regulates their cellular localization and function. Altered levels of p11 are implicated in the pathophysiology of several forms of cancer, psychiatric disorders, and neurodegeneration. Via interactions with ion channels and receptors, p11 modulates therapeutic actions of drugs targeting brain disorders. By serving as a plasminogen receptor, p11 plays an important role in plasmin generation, fibrinolysis, angiogenesis, tumor progression, and metastasis. Here, we review mechanisms whereby p11 regulates functions of ion channels and receptors in health and disease states.
p11（S100A10、膜联蛋白 II 轻链、钙粒蛋白 I 轻链）是一种多功能蛋白，与膜联蛋白 A2 形成异四聚体复合物，特别是在细胞膜上。p11 可单独或与膜联蛋白 A2 一起与多种离子通道和受体相互作用，并调节它们的细胞定位和功能。p11 水平的改变与多种形式的癌症、精神疾病和神经退行性变的病理生理学有关。通过与离子通道和受体的相互作用，p11 调节针对脑部疾病的药物的治疗作用。作为纤溶酶原受体，p11 在纤溶酶生成、纤维蛋白溶解、血管生成、肿瘤进展和转移中发挥重要作用。在这里，我们综述了 p11 在健康和疾病状态下调节离子通道和受体功能的机制。
