Osmanağaoğlu M A, Atasaral T, Baltaci D, Bozkaya H
Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynecology, Trabzon, Turkey.
Climacteric. 2006 Dec;9(6):464-72. doi: 10.1080/13697130600997775.
To compare the effect of different formulations of continuous combined hormone therapy on sexual performance in naturally postmenopausal women.
A total of 158 postmenopausal women were enrolled and prospectively randomized to the single-blind study. Fifty-four women received tibolone 2.5 mg, 53 received 2 mg estradiol and 2 mg dienogest (E2/dienogest), and 51 did not receive any menopausal therapy. The patients were monitored after 6 months. Attitudes of sexuality were evaluated by using the Rosen's female sexual function index.
Compared with E2/dienogest and the control group, tibolone treatment was associated with more improvement of sexual performance, including sexual desire, sexual arousal and satisfaction. Both of the hormone therapies decreased frequencies of vaginal dryness and painful intercourse.
Tibolone has more positive effects on the sexual dysfunction of postmenopausal women and may be an alternative to the E2/dienogest preparation in postmenopausal women with sexual dysfunction.
比较不同配方的连续联合激素疗法对自然绝经后女性性功能的影响。
共纳入158名绝经后女性，并前瞻性随机分组至单盲研究。54名女性接受2.5毫克替勃龙治疗，53名接受2毫克雌二醇和2毫克地诺孕素（E2/地诺孕素）治疗，51名未接受任何绝经治疗。6个月后对患者进行监测。使用罗森女性性功能指数评估性态度。
与E2/地诺孕素组和对照组相比，替勃龙治疗使性功能有更多改善，包括性欲、性唤起和满意度。两种激素疗法均降低了阴道干涩和性交疼痛的发生率。
替勃龙对绝经后女性性功能障碍有更积极的影响，对于有性功能障碍的绝经后女性，可能是E2/地诺孕素制剂的替代选择。
