单克隆抗体与假定的Bo5（CD5）簇的竞争性结合。
Competitive binding with putative Bo5 (CD5) cluster of monoclonal antibodies.
作者信息
Howard C J, Sopp P, Parsons K R
机构信息
Agricultural and Food Research Council, Institute for Animal Health, Compton Laboratory, Newbury, Berkshire, UK.
出版信息
Vet Immunol Immunopathol. 1991 Jan;27(1-3):147-51. doi: 10.1016/0165-2427(91)90093-r.
The relationship of seven monoclonal antibodies, putatively to the Bo5 (CD5) antigen, was tested. Five of the mAbs were confirmed to be directed against the Bo5 antigen. Three mAbs, CC29, BLT-1 and 8C11, effectively blocked binding to bovine PBM of mAb CC17, previously reported to be directed against this antigen. MAb 8-3F4 also blocked binding of mAb CC17, but less effectively than the others. MAbs IL-A67 and 79-5 did not inhibit binding of mAb CC17 because of antibody allelic specificity or technical reasons.
对七种推测针对Bo5（CD5）抗原的单克隆抗体之间的关系进行了检测。其中五种单克隆抗体被证实是针对Bo5抗原的。三种单克隆抗体CC29、BLT-1和8C11有效地阻断了先前报道针对该抗原的单克隆抗体CC17与牛外周血单核细胞（PBM）的结合。单克隆抗体8-3F4也阻断了单克隆抗体CC17的结合，但效果不如其他三种。由于抗体等位基因特异性或技术原因，单克隆抗体IL-A67和79-5没有抑制单克隆抗体CC17的结合。
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