多粘菌素B的作用方式：对枯草芽孢杆菌抗性突变体的生理学研究
Mode of action of polymyxin B: physiological studies with Bacillus subtilis-resistant mutant.
作者信息
Galizzi A, Cacco G, Siccardi A G, Mazza G
出版信息
Antimicrob Agents Chemother. 1975 Sep;8(3):366-9. doi: 10.1128/AAC.8.3.366.
Abstract
Polymyxin B resistance in Bacillus subtilis can be suppressed by the synergistic action of lysozyme or of an analogous cell wall lytic activity released by B. subtilis spores during germination. Such a synergistic effect is probably due to partial cell-wall digestion by lysozyme that allows polymyxin to reach its site of action and is therefore distinct from the analogous synergistic effect described by other authors in Escherichia coli. In the latter case polymyxin B probably damaged the outer membrane, allowing lysozyme to reach and digest the cell wall.
摘要
枯草芽孢杆菌对多粘菌素B的抗性可被溶菌酶或枯草芽孢杆菌孢子萌发过程中释放的类似细胞壁溶解活性的协同作用所抑制。这种协同效应可能是由于溶菌酶对细胞壁的部分消化，使多粘菌素能够到达其作用位点，因此不同于其他作者在大肠杆菌中描述的类似协同效应。在后一种情况下，多粘菌素B可能破坏了外膜，使溶菌酶能够到达并消化细胞壁。
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