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Mode of action of polymyxin B: physiological studies with Bacillus subtilis-resistant mutant.多粘菌素B的作用方式：对枯草芽孢杆菌抗性突变体的生理学研究
Antimicrob Agents Chemother. 1975 Sep;8(3):366-9. doi: 10.1128/AAC.8.3.366.
2
Outgrowth and vegetative growth inhibition of Bacillus subtilis spores after transient exposure to polymyxin B.短暂暴露于多粘菌素B后枯草芽孢杆菌孢子的生长和营养生长抑制
J Bacteriol. 1978 May;134(2):680-2. doi: 10.1128/jb.134.2.680-682.1978.
3
[Isolation and characterization of mutants of Bacillus subtilis resistant to polymyxin].
Boll Soc Ital Biol Sper. 1975 Feb 15;51(3):99-105.
4
Decreased particulate NADH oxidase activity in Bacillus subtilis spores after polymyxin B treatment.多粘菌素B处理后枯草芽孢杆菌孢子中颗粒状NADH氧化酶活性降低。
J Gen Microbiol. 1986 Feb;132(2):277-87. doi: 10.1099/00221287-132-2-277.
5
Inhibition of Escherichia coli growth and respiration by polymyxin B covalently attached to agarose beads.与琼脂糖珠共价连接的多粘菌素B对大肠杆菌生长和呼吸的抑制作用。
Biochemistry. 1977 Apr 19;16(8):1642-8. doi: 10.1021/bi00627a019.
6
Outer membrane permeability barrier disruption by polymyxin in polymyxin-susceptible and -resistant Salmonella typhimurium.多粘菌素对多粘菌素敏感和耐药的鼠伤寒沙门氏菌外膜通透性屏障的破坏作用
Antimicrob Agents Chemother. 1981 Apr;19(4):578-83. doi: 10.1128/AAC.19.4.578.
7
Phenotypic reversion in some early blocked sporulation mutants of Bacillus subtilis: isolation and phenotype identification of partial revertants.枯草芽孢杆菌一些早期阻断芽孢形成突变体中的表型回复：部分回复突变体的分离与表型鉴定
J Bacteriol. 1971 Oct;108(1):241-7. doi: 10.1128/jb.108.1.241-247.1971.
8
Disruption of the Escherichia coli outer membrane permeability barrier by immobilized polymyxin B.固定化多粘菌素B对大肠杆菌外膜通透性屏障的破坏作用
J Antibiot (Tokyo). 1977 Dec;30(12):1087-92. doi: 10.7164/antibiotics.30.1087.
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Nucleotide sequence and regulation of a new putative cell wall hydrolase gene, cwlD, which affects germination in Bacillus subtilis.一种影响枯草芽孢杆菌萌发的新的假定细胞壁水解酶基因cwlD的核苷酸序列及调控
J Bacteriol. 1995 Oct;177(19):5582-9. doi: 10.1128/jb.177.19.5582-5589.1995.
10
Phenotypic reversion in some early blocked sporulation mutants of Bacillus subtilis. Genetic study of polymyxin resistant partial revertants.枯草芽孢杆菌一些早期阻断芽孢形成突变体中的表型回复。多粘菌素抗性部分回复体的遗传学研究。
Mol Gen Genet. 1971;112(3):243-54.

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Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles.炔基双苯并咪唑的革兰氏阴性协同作用和作用机制。
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Front Cell Infect Microbiol. 2019 Apr 30;9:128. doi: 10.3389/fcimb.2019.00128. eCollection 2019.
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Isolation, pure culture, and characterization of "Candidatus Arsenophonus arthropodicus," an intracellular secondary endosymbiont from the hippoboscid louse fly Pseudolynchia canariensis.来自虱蝇（Pseudolynchia canariensis）的细胞内次生内共生菌“类节肢动物嗜砷菌（Candidatus Arsenophonus arthropodicus）”的分离、纯培养及特性鉴定
Appl Environ Microbiol. 2006 Apr;72(4):2997-3004. doi: 10.1128/AEM.72.4.2997-3004.2006.

本文引用的文献

1
A fluorescent derivative of polymyxin: its preparation and use in studying the site of action of the antibiotic.多粘菌素的一种荧光衍生物：其制备及其在研究该抗生素作用位点中的应用。
J Gen Microbiol. 1955 Apr;12(2):226-36. doi: 10.1099/00221287-12-2-226.
2
Effect of polymyxin on the lysis of Neisseria catarrhalis by lysozyme.多粘菌素对溶菌酶裂解卡他莫拉菌的影响。
J Bacteriol. 1957 Dec;74(6):788-93. doi: 10.1128/jb.74.6.788-793.1957.
3
A cell-wall lytic enzyme associated with spores of Bacillus species.一种与芽孢杆菌属孢子相关的细胞壁裂解酶。
J Gen Microbiol. 1957 Feb;16(1):236-49. doi: 10.1099/00221287-16-1-236.
4
The absorption of polymyxin E by bacteria and bacterial cell walls and its bactericidal action.细菌及细菌细胞壁对多粘菌素E的吸收及其杀菌作用。
J Gen Microbiol. 1953 Dec;9(3):454-66. doi: 10.1099/00221287-9-3-454.
5
Absorption of polymyxin by bacteria.细菌对多粘菌素的吸收。
Nature. 1953 Apr 11;171(4354):644-5. doi: 10.1038/171644a0.
6
Interaction of antibiotics with membranes: polymyxin B and gramicidin S.
Biochim Biophys Acta. 1972 Jan 17;255(1):358-64. doi: 10.1016/0005-2736(72)90034-x.
7
Electron microscopy of effect of polymyxin on Escherichia coli lipopolysaccharide.多粘菌素对大肠杆菌脂多糖作用的电子显微镜观察
J Bacteriol. 1969 Nov;100(2):1128-9. doi: 10.1128/jb.100.2.1128-1130.1969.
8
Susceptibility to polymyxin B in penicillin G-induced Proteus mirabilis L forms and spheroplasts.青霉素G诱导的奇异变形杆菌L型和原生质体对多粘菌素B的敏感性。
J Bacteriol. 1969 May;98(2):347-50. doi: 10.1128/jb.98.2.347-350.1969.

多粘菌素B的作用方式：对枯草芽孢杆菌抗性突变体的生理学研究

Mode of action of polymyxin B: physiological studies with Bacillus subtilis-resistant mutant.

作者信息

Galizzi A, Cacco G, Siccardi A G, Mazza G

出版信息

Antimicrob Agents Chemother. 1975 Sep;8(3):366-9. doi: 10.1128/AAC.8.3.366.

DOI:10.1128/AAC.8.3.366
PMID:170857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429319/
Abstract

Polymyxin B resistance in Bacillus subtilis can be suppressed by the synergistic action of lysozyme or of an analogous cell wall lytic activity released by B. subtilis spores during germination. Such a synergistic effect is probably due to partial cell-wall digestion by lysozyme that allows polymyxin to reach its site of action and is therefore distinct from the analogous synergistic effect described by other authors in Escherichia coli. In the latter case polymyxin B probably damaged the outer membrane, allowing lysozyme to reach and digest the cell wall.

摘要

枯草芽孢杆菌对多粘菌素B的抗性可被溶菌酶或枯草芽孢杆菌孢子萌发过程中释放的类似细胞壁溶解活性的协同作用所抑制。这种协同效应可能是由于溶菌酶对细胞壁的部分消化，使多粘菌素能够到达其作用位点，因此不同于其他作者在大肠杆菌中描述的类似协同效应。在后一种情况下，多粘菌素B可能破坏了外膜，使溶菌酶能够到达并消化细胞壁。