Müller H, Weier S, Schneider M, Hübner K, Stutte H J
Senckenbergisches Zentrum der Pathologie im Klinikum, J. W. Goethe-Universität, Frankfurt.
Verh Dtsch Ges Pathol. 1990;74:149-54.
Bone marrow biopsies of 23 HIV-1 infected patients and 29 patients with myelodysplastic disorders were examined histologically by immuno- and enzyme-histochemical techniques and morphometrical methods. The nucleolar organizer regions (AgNOR) were demonstrated and visually counted. Hypercellularity in marrows of AIDS patients is substantially caused by an increase of erythropoiesis and CD68+ macrophages/reticular cells. However, hypercellularity in preleukemia results from hyperplasia of all hematological cell lines and CD68+ bone marrow macrophages/reticular cells. AgNOR count is positively correlated with granulo- and erythropoiesis in preleukemia. In AIDS there is such a positive correlation between AgNOR count and granulopoiesis whereas an inverse relationship appears in erythropoiesis. The results suggest that HIV-associated bone marrow alterations differ from merely reactive changes and are related to myelodysplastic disorders.
采用免疫组织化学、酶组织化学技术及形态计量学方法，对23例HIV-1感染患者和29例骨髓增生异常综合征患者的骨髓活检组织进行了组织学检查。对核仁组织区（AgNOR）进行了显示和视觉计数。艾滋病患者骨髓细胞增多主要是由红细胞生成及CD68+巨噬细胞/网状细胞增多所致。然而，白血病前期的骨髓细胞增多是由所有血液学细胞系及CD68+骨髓巨噬细胞/网状细胞增生引起的。在白血病前期，AgNOR计数与粒细胞生成及红细胞生成呈正相关。在艾滋病中，AgNOR计数与粒细胞生成呈正相关，而与红细胞生成呈负相关。结果表明，HIV相关的骨髓改变不同于单纯的反应性改变，且与骨髓增生异常综合征有关。
