Candido A, Rossi P, Menichella G, Pierelli L, Pizzigallo E, Camilli G, Rumi C, Mango G
Servizio di Ematologia, Università Cattolica del S. Cuore (U.C.S.C.), Roma, Italy.
Haematologica. 1990 Jul-Aug;75(4):327-33.
In HIV infection, numerous alterations of the hematopoietic system, with frequent cytopenias in peripheral blood and dysplasia of the bone marrow, have been observed. In order to assess the incidence of the myelodysplastic anomalies, 69 bone marrow aspirate smears from 47 patients with group IV HIV infection, as classified by CDC, have been studied. Various degrees of myelodysplastic alterations were found in all cases; however, dysgranulopoiesis was more frequent and more accentuated than other kinds of dyshematopoiesis. Intense vacuolization, especially in the granuloblastic series, was very frequent. It is felt that a bone marrow configuration that is highly indicative of overt AIDS can be sketched. The human immune deficiency virus may be either directly or indirectly responsible for myelodysplastic alterations.
在HIV感染中，已观察到造血系统的诸多改变，外周血中常有血细胞减少以及骨髓发育异常。为评估骨髓发育异常异常的发生率，我们研究了疾病控制与预防中心（CDC）分类的47例IV组HIV感染患者的69份骨髓穿刺涂片。所有病例均发现了不同程度的骨髓发育异常改变；然而，粒细胞生成异常比其他类型的造血异常更常见且更明显。强烈的空泡化，尤其是在粒细胞系中，非常常见。可以勾勒出一种高度提示明显艾滋病的骨髓形态。人类免疫缺陷病毒可能直接或间接导致骨髓发育异常改变。
