Dörmer P, Mergenthaler H G
GSF-Institut für Experimentelle Hämatologie, München.
Verh Dtsch Ges Pathol. 1990;74:65-74.
Cases of myelodysplastic syndrome (MDS) that have evolved into overt leukemia may be retrospectively termed preleukemia. Studies with X-chromosomal markers in females strongly suggest that preleukemia originates from transformation of a very early hemopoietic stem cell. Growth characteristics of myeloblasts in preleukemia indicate that some of the cases already represent early stages of acute leukemia. In other preleukemias clonal evolution towards overt leukemia can be observed. This apparently involves neoplastic transformation of a granulocytic determined progenitor cell.
已演变为明显白血病的骨髓增生异常综合征（MDS）病例可被追溯性地称为白血病前期。对女性X染色体标记物的研究有力地表明，白血病前期起源于非常早期造血干细胞的转化。白血病前期原粒细胞的生长特征表明，其中一些病例已经处于急性白血病的早期阶段。在其他白血病前期病例中，可以观察到向明显白血病的克隆进化。这显然涉及粒系定向祖细胞的肿瘤性转化。
