CD8的表位特异性结合调节T细胞的激活和细胞毒性的诱导。
Epitope-specific binding of CD8 regulates activation of T cells and induction of cytotoxicity.
作者信息
Tomonari K, Spencer S
机构信息
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, UK.
出版信息
Int Immunol. 1990;2(12):1189-94. doi: 10.1093/intimm/2.12.1189.
Functions of the CD8 molecule were examined to determine whether CD8 is merely a ligand-binding molecule and/or is involved in signal transduction. Using KT112 (anti-CD8 beta), CD8 was demonstrated to transduce an activation signal leading to cytotoxicity. Conformational changes of the CD8 molecule might be responsible for the activation, because (i) KT15 (anti-monomorphic CD8 alpha), but not antibodies specific for polymorphic CD8 alpha determinants, abrogated KT112 (anti-CD8 beta)-induced cytotoxicity without blocking the binding of KT112, whilst (ii) KT112 (anti-CD8 beta) inhibited KT15 (anti-monomorphic CD8 alpha)-mediated augmentation of proliferation triggered by a V beta 11-specific antibody without blocking the binding of KT15.
研究了CD8分子的功能，以确定CD8是否仅仅是一种配体结合分子和/或是否参与信号转导。使用KT112（抗CD8β），证明CD8可转导导致细胞毒性的激活信号。CD8分子的构象变化可能是激活的原因，因为：（i）KT15（抗单态性CD8α），而非针对多态性CD8α决定簇的特异性抗体，可消除KT112（抗CD8β）诱导的细胞毒性，而不阻断KT112的结合；同时（ii）KT112（抗CD8β）抑制KT15（抗单态性CD8α）介导的由Vβ11特异性抗体触发的增殖增强，而不阻断KT15的结合。
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