Hancock Barry W, Nazir Kauzer, Everard Janet E
Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, U.K.
J Reprod Med. 2006 Oct;51(10):764-6.
To report the Sheffield experience with persistent gestational trophoblastic neoplasia (GTN) after partial hydatidiform mole (PHM) and to review worldwide experience.
All PHMs registered at the Sheffield Trophoblast Centre between 1991 and 2004 were included in this retrospective study. Any case of PHM leading to persistent GTN was reviewed centrally by an expert gynecologic pathologist. Clinical features, treatment and outcome were recorded.
During the 14-year study period 3189 PHMs were registered. Forty-one developed persistent GTN. Central histopathology review confirmed PHM in only 14 cases (0.91% of all those registered). Twelve scored low and 2 high risk according to International Federation of Gynecology and Obstetrics 2000 criteria. During the same period, 271 cases of persistent GTN originally registered as complete hydatidiform mole were reviewed; 3 were found to be PHMs (2 low, 1 high risk). In all, 15 of 17 persistent PHMs required chemotherapy.
Persistent GTN requiring chemotherapy can occasionally occur after PHM; surveillance of all cases continues to be recommended.
报告谢菲尔德关于部分性葡萄胎（PHM）后持续性妊娠滋养细胞肿瘤（GTN）的经验，并回顾全球经验。
本回顾性研究纳入了1991年至2004年间在谢菲尔德滋养细胞中心登记的所有部分性葡萄胎病例。任何导致持续性GTN的部分性葡萄胎病例均由一名专家妇科病理学家进行集中审查。记录临床特征、治疗情况及结果。
在14年的研究期间，共登记了3189例部分性葡萄胎。41例发展为持续性GTN。中心组织病理学审查仅在14例中确诊为部分性葡萄胎（占所有登记病例的0.91%）。根据国际妇产科联盟2000年标准，12例为低风险，2例为高风险。在同一时期，对最初登记为完全性葡萄胎的271例持续性GTN病例进行了审查；发现其中3例为部分性葡萄胎（2例低风险，1例高风险）。总共17例持续性部分性葡萄胎中有15例需要化疗。
部分性葡萄胎后偶尔会发生需要化疗的持续性GTN；仍建议对所有病例进行监测。
