Hoem D, Viste A, Horn A, Gislason H, Søndenaa K
Department of Surgery, Haukeland University Hospital, Bergen, Norway.
Hepatogastroenterology. 2006 Sep-Oct;53(71):655-9.
BACKGROUND/AIMS: The aim was to study prospectively primary endoscopic treatment of CBD stones and further the long-term need for renewed gallstone disease interventions, defined as short- and long-term outcome.
Seven years prospective follow-up of 101 consecutive patients with CBD stones who underwent endoscopic treatment with the intent of primarily achieving duct clearance.
Many patients underwent several endoscopy sessions before stone clearance was completed in 83%. Eleven patients were treated surgically, 2 patients received a permanent stent, and the remaining 3 became stone free with other means. Complications occurred in 47 patients. During follow-up, 31 patients were readmitted for gallstone disease and 15 of these had recurrent CBD stones. Ten percent (8/78) of patients with the gallbladder in situ had acute cholecystitis during follow-up and late cholecystectomy was carried out in 22%. Risk factors for new gallstone disease were an in situ gallbladder containing stones and previous episodes of CBD stones.
A goal of complete CBD stone clearance with ERC and ES proved to be relatively resource consuming. Subsequent cholecystectomy after duct clearance for CBD should be advised when the gallbladder lodges gallstones, especially in younger patients. Recurrent CBD stones were not influenced by cholecystectomy.
背景/目的:本研究旨在对胆总管结石的初次内镜治疗进行前瞻性研究,并进一步探讨对复发性胆石症进行再次干预的长期必要性,即短期和长期疗效。
对101例连续接受内镜治疗的胆总管结石患者进行了7年的前瞻性随访,主要目的是实现胆管通畅。
许多患者在83%的患者结石清除完成之前接受了多次内镜检查。11例患者接受了手术治疗,2例患者置入了永久性支架,其余3例通过其他方法实现了结石清除。47例患者出现了并发症。在随访期间,31例患者因胆石症再次入院,其中15例有复发性胆总管结石。胆囊未切除的患者中有10%(8/78)在随访期间发生了急性胆囊炎,22%的患者接受了晚期胆囊切除术。新发胆石症的危险因素是胆囊内有结石以及既往有胆总管结石发作史。
事实证明,通过内镜逆行胰胆管造影术(ERC)和内镜括约肌切开术(ES)实现完全清除胆总管结石这一目标相对耗费资源。当胆囊内有结石时,尤其是年轻患者,建议在胆管通畅后进行胆囊切除术。胆囊切除术对复发性胆总管结石没有影响。