Tanaka Moritsugu, Sawai Hirozumi, Okada Yiuji, Yamamoto Minoru, Funahashi Hitoshi, Takeyama Hiromitsu, Manabe Tadao
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Japan.
Hepatogastroenterology. 2006 Sep-Oct;53(71):783-7.
BACKGROUND/AIMS: We analyzed clinicopathologic and imaging findings of intraductal papillary-mucinous tumors (IPMTs) and mucinous cystic tumors (MCTs) of the pancreas to evaluate the difference between IPMTs and MCTs, and to identify the signs indicative of malignancy in IPMTs.
Clinicopathological features of 20 patients with IPMT and six patients with MCT of the pancreas were studied.
The patients with IPMT comprised 16 males and four females with a mean age of 62.9 years. Eighty percent of IPMTs were located in the pancreatic head, and the mean tumor size was 38.6mm. Recurrence was observed in one patient, who died of IPM adenocarcinoma. In contrast, all patients with MCT were females, with a mean age of 53.0 years. None of the MCTs arose in the pancreatic head, and the mean tumor size was 42.7mm. One patient died of MC adenocarcinoma, but all of the others survived without recurrence. The difference in gender, location of the tumor, and connection to the pancreatic duct reached statistical significance between IPMTs and MCTs. A significant connection to the pancreatic duct and high level of serum carbohydrate antigen 19-9 (CA19-9) was observed in the adenocarcinoma and moderate dysplasia groups of IPMT.
The main duct type and an elevation of serum CA19-9 level suggested malignancy in IPMTs.
背景/目的：我们分析了胰腺导管内乳头状黏液性肿瘤（IPMTs）和黏液性囊性肿瘤（MCTs）的临床病理及影像学表现，以评估IPMTs与MCTs之间的差异，并确定IPMTs中提示恶性的征象。
研究了20例胰腺IPMT患者和6例胰腺MCT患者的临床病理特征。
IPMT患者包括16例男性和4例女性，平均年龄62.9岁。80%的IPMT位于胰头，平均肿瘤大小为38.6mm。1例患者复发，死于IPMT腺癌。相比之下，所有MCT患者均为女性，平均年龄53.0岁。所有MCT均未发生于胰头，平均肿瘤大小为42.7mm。1例患者死于MC腺癌，但其他所有患者均存活且无复发。IPMTs与MCTs在性别、肿瘤位置及与胰管的关系方面的差异具有统计学意义。在IPMT的腺癌和中度发育异常组中观察到与胰管的显著关联及血清糖类抗原19-9（CA19-9）水平升高。
主胰管型和血清CA19-9水平升高提示IPMTs具有恶性特征。
