Unit of Endocrine, Digestive and Emergency Surgery, Department of Biomedical Sciences and Human Oncology, Section of General and Oncologic Surgery, University Medical School of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy.
World J Gastroenterol. 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682.
The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications and matching the key words "pancreatic mucinous cystic neoplasm", "pancreatic mucinous cystic tumour", "pancreatic mucinous cystic mass", "pancreatic cyst", and "pancreatic cystic neoplasm" to identify English language articles describing the diagnosis and treatment of the mucinous cystic neoplasm of the pancreas. In total, 16 322 references ranging from January 1969 to December 2009 were analysed and 77 articles were identified. No articles published before 1996 were selected because MCNs were not previously considered to be a completely autonomous disease. Definition, epidemiology, anatomopathological findings, clinical presentation, preoperative evaluation, treatment and prognosis were reviewed. MCNs are pancreatic mucin-producing cysts with a distinctive ovarian-type stroma localized in the body-tail of the gland and occurring in middle-aged females. The majority of MCNs are slow growing and asymptomatic. The prevalence of invasive carcinoma varies between 6% and 55%. Preoperative diagnosis depends on a combination of clinical features, tumor markers, computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound with cyst fluid analysis, and positron emission tomography-CT. Surgery is indicated for all MCNs.
本研究旨在探讨胰腺黏液性囊腺瘤（MCN）的实际处理方法。2009 年 12 月通过查阅 PubMed MEDLINE 上的文献并匹配“胰腺黏液性囊腺瘤”、“胰腺黏液性囊状肿瘤”、“胰腺黏液性囊状肿块”、“胰腺囊肿”和“胰腺囊状肿瘤”等关键词进行了系统评价，以确定描述胰腺黏液性囊腺瘤的诊断和治疗的英文文献。共分析了 1969 年 1 月至 2009 年 12 月期间的 16322 篇参考文献，确定了 77 篇文章。由于此前 MCN 并未被认为是一种完全独立的疾病，因此未选择 1996 年以前发表的文章。本文回顾了 MCN 的定义、流行病学、解剖病理学发现、临床表现、术前评估、治疗和预后。MCN 是一种胰腺黏液性囊，具有独特的卵巢样基质，位于胰体-尾部，发生于中年女性。大多数 MCN 生长缓慢且无症状。侵袭性癌的发生率在 6%至 55%之间变化。术前诊断取决于临床特征、肿瘤标志物、计算机断层扫描（CT）、磁共振成像（MRI）、内镜超声联合囊液分析以及正电子发射断层扫描-CT 的综合判断。所有 MCN 均需手术治疗。
