Werneke U, Northey S, Bhugra D
Department of Psychiatry, Homerton University Hospital, London, UK.
Acta Psychiatr Scand. 2006 Dec;114(6):384-97. doi: 10.1111/j.1600-0447.2006.00890.x.
Many patients with depression suffer from sexual dysfunction and sexual dysfunction is a recognized side-effect of antidepressants. The aim of this review was to examine the prevalence of psychosexual dysfunction associated with antidepressants, and to review treatment options which are specific to the affected component of sexual functioning and antidepressants.
Comprehensive literature review using Medline and Cochrane databases.
Up to 70% of patients with depression may have sexual dysfunction. Tricyclic antidepressants, selective-serotonin reuptake inhibitors and venlafaxine are most and the non-serotonergic antidepressants and duloxetine least likely to produce sexual dysfunction. Pharmacological treatment options include antidepressants less likely associated or 'antidotes' to reverse sexual dysfunction.
Sexual dysfunction may be a preventable or treatable side-effect of antidepressants. Patients need routinely to be asked about sexual function to identify problems early. If sexual dysfunction is ignored it may maintain the depression, compromise treatment outcome and lead to non-compliance.
许多抑郁症患者存在性功能障碍，且性功能障碍是抗抑郁药公认的副作用。本综述的目的是研究与抗抑郁药相关的性心理功能障碍的患病率，并综述针对性功能受影响成分及抗抑郁药的具体治疗选择。
使用Medline和Cochrane数据库进行全面的文献综述。
高达70%的抑郁症患者可能存在性功能障碍。三环类抗抑郁药、选择性5-羟色胺再摄取抑制剂和文拉法辛最易导致性功能障碍，而非5-羟色胺能抗抑郁药和度洛西汀导致性功能障碍的可能性最小。药物治疗选择包括与性功能障碍关联较小的抗抑郁药或逆转性功能障碍的“解药”。
性功能障碍可能是抗抑郁药可预防或可治疗的副作用。需要定期询问患者的性功能情况以便早期发现问题。如果性功能障碍被忽视，可能会使抑郁症持续存在、影响治疗效果并导致患者不依从治疗。
