Manuli Alfredo, Maggio Maria Grazia, De Pasquale Paolo, Raciti Loredana, Filoni Serena, Portaro Simona, Pucciarelli Gianluca, Calabrò Rocco Salvatore
Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
J Clin Med. 2024 Dec 30;14(1):152. doi: 10.3390/jcm14010152.
: Sexual dysfunction (SD) in Parkinson's Disease (PD) patients is a common and distressing concern, although it remains an underdiagnosed and undertreated condition. Indeed, the prevalence of SD in PD ranges from 42.6% to 79% in men and from 36% to 87.5% in women. PD-related SD etiology is multifactorial and includes biological, psychological, and socio-relational factors. In a previous multicenter study on 203 PD patients, we found that there was no gender difference in dysfunction severity, although men were significantly more affected by SD than women. : This paper is a secondary analysis of this previous multicenter study, and aims to investigate the potential risk factors that contribute to SD. The relationship between dysfunction and the experimental factors was assessed using Generalized Linear Mixed-Effects (GLME) model. : The final analysis was conducted on a sample of 177 patients (76 women), after excluding individuals with incomplete data, non-compliance with inclusion criteria, or delays in assessment tool administration. The analysis, performed using the GLME model (R = 0.68), revealed that gender ( = 0.01), age ( = 0.02), and depression status (HAMD) ( = 0.01) were significant predictors of SD. In contrast, other factors considered in the model, such as diabetes, and autonomic symptoms, did not significantly influence SD. : This study demonstrates that age, gender, and depression are important predictors of SD in patients with PD. Although SD is a common NMS in PD patients, it is often neglected in clinical practice and the research on this hot topic is still poor. Then, a multidisciplinary approach, including nursing and coaching, is mandatory in order to improve sexual health in this patient population.
帕金森病（PD）患者的性功能障碍（SD）是一个常见且令人苦恼的问题，尽管它仍然是一种诊断不足和治疗不足的病症。事实上，PD患者中SD的患病率在男性中为42.6%至79%，在女性中为36%至87.5%。与PD相关的SD病因是多因素的，包括生物学、心理和社会关系因素。在之前一项对203名PD患者的多中心研究中，我们发现功能障碍严重程度没有性别差异，尽管男性受SD影响的程度明显高于女性。 本文是对之前这项多中心研究的二次分析，旨在调查导致SD的潜在风险因素。使用广义线性混合效应（GLME）模型评估功能障碍与实验因素之间的关系。 在排除数据不完整、不符合纳入标准或评估工具施用延迟的个体后，对177名患者（76名女性）的样本进行了最终分析。使用GLME模型（R = 0.68）进行的分析显示，性别（P = 0.01）、年龄（P = 0.02）和抑郁状态（汉密尔顿抑郁量表）（P = 0.01）是SD的重要预测因素。相比之下，模型中考虑的其他因素，如糖尿病和自主神经症状，对SD没有显著影响。 这项研究表明，年龄、性别和抑郁是PD患者SD的重要预测因素。尽管SD是PD患者中常见的非运动症状，但在临床实践中常常被忽视，对此热门话题的研究仍然很少。因此，为了改善这一患者群体的性健康，必须采取包括护理和指导在内的多学科方法。
