Tzingounis Anastassios V, Nicoll Roger A
Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA.
Neuron. 2006 Nov 9;52(3):403-7. doi: 10.1016/j.neuron.2006.10.016.
Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.
Arc/Arg3.1是一种与记忆巩固相关的效应即早基因。尽管在十年前就已克隆出来，但Arc/Arg3.1在大脑中的生理作用仍不清楚。本期《神经元》杂志上的四篇论文探讨了这一功能。这些研究表明，Arc/Arg3.1调节内吞作用机制的两个组成部分——内吞蛋白3和发动蛋白2。在小鼠中对Arc/Arg3.1进行基因敲除或在培养物中过表达表明，Arc/Arg3.1调节AMPA受体的转运和突触可塑性。最后，Arc/Arg3.1基因敲除小鼠表现出记忆保持缺陷。这些最新进展为这种广为人知的活动依赖性神经元标记物的功能提供了新的见解。
