Iadarola M J, Ofri D, Kleinman J E
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
Life Sci. 1991;48(20):1919-30. doi: 10.1016/0024-3205(91)90224-y.
Three peptide neuromodulators that are found in high concentration in the substantia nigra: dynorphin A 1-8, met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.
强啡肽A 1-8、甲硫氨酸脑啡肽-精氨酸-甘氨酸-亮氨酸和P物质。两组间P物质和强啡肽无变化。然而，脑啡肽原衍生肽在精神分裂症组中显著升高。通过高压液相色谱法将免疫反应性鉴定为真正的甲硫氨酸脑啡肽-精氨酸-甘氨酸-亮氨酸。数据表明，与强啡肽和P物质相比，黑质脑啡肽肽存在不同的调控机制，并且前一种系统在精神分裂症中可能紊乱。
